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Antimycin A from Streptomyces sp

Antimycin A from Streptomyces sp

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商品描述

A8674,Antimycin A from Streptomyces sp.,SIGMA:

性质:

Related Categories AN-AZ, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antifungal,
Antineoplastic and Immunosuppressive Antibiotics, Bioactive Small Molecule Alphabetical Index, Chemical Structure Class, Inhibits an Enzyme, Mechanism of Action, Peptides, Spectrum of Activity, 一氧化氮和细胞应激, 生素, 生化试, 生物活性小分子, 线粒体抑制剂, 胞信号转导和神经科学, 细胞应, 细胞生物学 
InChI Key   UIFFUZWRFRDZJC-RBVQMQRASA-N
Quality Level   PREMIUM
Mode of action   enzyme | inhibits
antibiotic activity spectrum   fungi
storage temp.   −20°C

产品描述:

Biochem/physiol Actions

Inhibitor of electron transfer at complex III. Induces apoptosis.

包装

25, 50, 100 mg in glass bottle

Quality

A mixture of antimycins.

Application

Antimycin A from Streptomyces sp. has been used:
• as a respiratory chain inhibitor in neuronal cultures
• in organello ATP production assay in Trypanosoma brucei cells
• in respiration assay for papillary thyroid carcinoma (PTC) cell lines

Antimycin A has been used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise

General description

Antimycin is produced by Streptomyces species.  It inhibits mitochondrial electron transport chain complex III and favors reactive oxygen species (ROS) production, impairing mitochondrial depolarization. It inhibits nitric oxide-mediated apoptosis and modulatescytochrome C release. It suppresses tumorigenesis in lung cancer cells and could be a potential therapeutic agent. 

Chemical structure: peptide




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