Related Categories |
B, Bioactive Small Molecule Alphabetical Index, Glycogen Synthase Kinase 3 (GSK3), Inhibitors, Inhibitors and Substrates,
Kinase/Phosphatase Biology, Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, Small Molecules for Stem Cell Biology, 分子生物学, 干细胞生物学, 生物活性小分子, 糖生物学, 细胞信号转导和神经科学, 细胞生物学, 翻译后修饰, 蛋白质组学
|
InChI Key | DDLZLOKCJHBUHD-WAVHTBQISA-N |
assay | ≥98% (HPLC) |
form | powder |
storage condition | protect from light |
color | dark red |
solubility | DMSO: >5 mg/mL |
shipped in | wet ice |
storage temp. | 2-8°C |
5, 25 mg in glass bottle
air sensitive
Product is sold for research and laboratory purposes in vitro and may not be used for any in vivo or therapeutic uses in humans, veterinary applications, or to make chemical derivatives.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
6-bromoindirubin-3′-oxime (BIO) has been used:
• in MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) cell proliferation assay
• as a medium supplement in embryonic stem cells (ESCs)
• for the inhibition of glycogen synthase kinase 3 β (GSK-3β) in human dermal papilla cells (hDPCs)
6-bromoindirubin-3′-oxime (BIO) is a potent, reversible and ATP-competitive GSK-3α/β inhibitor and the first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells. Human embryonic stem cells (hESCs) are maintained in the undifferentiated state through treatment with a GSK-3 inhibitor, BIO, under a feeder-free condition.
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
商品类别
|
*商品编号
|
商品名称
|
规格型号
|
SIGMA
|
08198-10MG
|
刺五加苷E
Eleutheroside E
|
10MG
|
SIGMA
|
12007C-500ML
|
胎牛血清
|
500ml/瓶
|
SIGMA
|
152463-250ML
|
2-甲基-2-丁醇
|
250ml/瓶
|
SIGMA
|
16005-1KG-R
|
多聚甲醛
|
1kg
|
SIGMA
|
16922-500G-F
|
Tryptone
(vegetable)
|
500g
|
SIGMA
|
202398-250G
|
聚乙二醇
|
250g/瓶
|
SIGMA
|
217263-5G
|
Sodium
thiosulfate
|
5g
|
SIGMA
|
281778-100ML
|
(3-Aminopropyl)trimethoxysilane
|
100ML
|
SIGMA
|
30070-10G
|
半胱胺
|
10G
|
SIGMA
|
31395-10G
|
葡聚糖硫酸酯 钠盐
|
10g
|
SIGMA
|
31395-50G
|
葡聚糖硫酸酯钠盐
|
50g
|
SIGMA
|
31417-100MG-F
|
葡聚糖
|
100mg
|
SIGMA
|
322415-1L
|
甲醇
|
1L/瓶
|
SIGMA
|
341584-25G
|
聚(乙烯醇)
|
25g
|
SIGMA
|
341584-500G
|
聚(乙烯醇)
|
500g
|
SIGMA
|
36733-250MG
|
(−)-Nicotine
|
250mg
|
SIGMA
|
44112-100G-F
|
Tween
20
|
100g
|
SIGMA
|
459836-500ML
|
Ethyl
alcohol
|
500ml/瓶
|
SIGMA
|
50839-25MG
|
梓醇苷
catalpol
|
25MG
|
SIGMA
|
557354-5MG
|
ROS
Inhibitor
|
5mg
|
SIGMA
|
57285-U
|
固相微萃取头组合套件
|
|
SIGMA
|
63559-250G
|
D-甘露糖醇
|
250g/瓶
|
SIGMA
|
63689-25ML-F
|
2-巯基乙醇
|
25ml
|
SIGMA
|
71504-250G
|
Sodium
phosphate monobasic monohydrate
|
250g
|
SIGMA
|
71507-250G
|
磷酸钠
一元 一水合物
|
250g
|
SIGMA
|
71640-250G
|
Sodium
phosphate dibasic
|
250g
|
SIGMA
|
72049-250G
|
硫代硫酸钠
|
250g
|
SIGMA
|
769193-1KG
|
Cremophor
A25
|
1kg
|
SIGMA
|
81253-250G
|
PEG6000
|
250g/瓶
|
SIGMA
|
81323-250G
|
聚乙二醇甲醚
|
250g/瓶
|
SIGMA
|
84097-250G
|
蔗糖
|
250g
|
SIGMA
|
90974-10MG
|
刺五加苷B
Eleutheroside B
|
10MG
|
SIGMA
|
93283-100ML
|
Tris-EDTA
buffer solution
|
100ml
|
SIGMA
|
A0500-100G
|
乙酰胺
|
100G
|
SIGMA
|
A1153-1MG
|
抑肽酶
来源于牛肺
|
1mg/瓶
|
SIGMA
|
A1410-5MG
|
放线菌素
D
|
5mg
|
SIGMA
|
A2547-100UL
|
Monoclonal
Anti-Actin, α-Smoot
|
100ul/支
|
SIGMA
|
A2942-100ML
|
两性霉素
B 溶液
|
100ml
|
SIGMA
|
A3656-5MG
|
5-Aza-2′-deoxycytidine
|
5mg
|
SIGMA
|
A3854-200UL
|
Monoclonal
Anti-β-Actin Peroxi
|
200ul
|
SIGMA
|
A4544-100G
|
L-Ascorbic
acid
|
100g
|
SIGMA
|
A6410-100UN
|
三磷酸腺苷双磷酸酶
来源于马铃薯
|
100un/支
|
SIGMA
|
A7736-1G
|
Albumin
human
|
1g
|
SIGMA
|
A7906-100G
|
Albumin
from Bovine Serum (ABS
|
100g/瓶
|
SIGMA
|
A8674-50MG
|
Antimycin
A
|
50mg
|
SIGMA
|
A9415-5MG
|
Actinomycin
D
|
5mg
|
SIGMA
|
A9525-5MG
|
人血管紧张素
II
|
5mg/瓶
|
SIGMA
|
A9731-1G
|
Albumin
human
|
1g/支
|
SIGMA
|
A9771-1G
|
FITC-albumin
|
1g
|
SIGMA
|
B1686-5MG
|
BIO
|
5mg
|
SIGMA
|
B1911-100ML
|
NBT
Liquid Substrate System
|
|
SIGMA
|
B2064-100G
|
Bovine
Serum Albumin
|
100g
|
SIGMA
|
B2261-25MG
|
Hoechst
33342
|
25mg
|
SIGMA
|
B2635-10G
|
Busulfan
|
10g
|
SIGMA
|
B5002-100MG
|
5-Bromo-2′-deoxyuridine
|
100mg
|
SIGMA
|
B5002-500MG
|
BrdU
|
500MG
|
SIGMA
|
B6542-5MG
|
Brefeldin
A
|
5mg/支
|
SIGMA
|
B6688-5MG
|
BMS
493
|
5mg
|
SIGMA
|
BP501
|
Levonorgestrel
|
100mg
|
SIGMA
|
C0130-100MG
|
胶原蛋白酶
|
100mg
|
SIGMA
|
C0424-10MG
|
pk11995
|
10mg
|
SIGMA
|
C0732-100G
|
西吡氯铵
|
|
SIGMA
|
C2401-1G
|
Crotaline
|
1g
|
SIGMA
|
C2674-100MG
|
胶原蛋白酶
|
100mg
|
SIGMA
|
C2674-1G
|
胶原蛋白酶
|
1g
|
SIGMA
|
C2674-500MG
|
胶原蛋白酶
|
500mg
|
SIGMA
|
C2687-100UL
|
Monoclonal
Anti-Calponin antib
|
100ul/支
|
SIGMA
|
C2759-100G
|
Carbonyl
cyanide 3-chloropheny
|
100g/瓶
|
SIGMA
|
C2759-100MG
|
Carbonyl
cyanide 3-chlorophenylhydrazone
|
100mg
|
SIGMA
|
C4555-5G
|
甲基-β-环糊精
|
5G
|
SIGMA
|
C5138-100MG
|
胶原蛋白酶
|
100mg
|
SIGMA
|
C5138-1G
|
胶原蛋白酶
|
1g
|
SIGMA
|
C5138-25MG
|
胶原蛋白酶
|
25mg
|
SIGMA
|
C5174-5MG
|
4′-Chlorodiazepam
|
5mg/支
|
SIGMA
|
C5670-100G
|
Calcium
chloride
|
100g
|
SIGMA
|
C6158-50G
|
结晶紫
|
50g
|
SIGMA
|
C7902-500G
|
氯化钙
|
500g
|
SIGMA
|
C8661-100G
|
氯化钴(II)
六水合物
|
100g/瓶
|
SIGMA
|
CDS021691-100MG
|
D-Glucosamine
|
100mg/支
|
SIGMA
|
D1556-250ML
|
OptiPrep
Density Gradient Medium
|
250ml
|
SIGMA
|
D2650-100ML
|
DMSO
|
100ml
|
SIGMA
|
D4693-1G
|
DISPASE
II
|
1g/瓶
|
SIGMA
|
D4902-25MG
|
Dexamethasone
|
25mg
|
SIGMA
|
D5025-375KU
|
Deoxyribonuclease
I from bovine pancrea
|
375KU
|
SIGMA
|
D5879-100ML
|
DMSO
|
100ml
|
SIGMA
|
D5879-500ML
|
DMSO
|
500ml
|
SIGMA
|
D6134-1G
|
2-Deoxy-D-Glucose
|
1g/瓶
|
SIGMA
|
D6750-100G
|
脱氧胆酸钠
|
100G
|
SIGMA
|
D8418-500ML
|
DMSO
|
500ml
|
SIGMA
|
D8555-5MG
|
N,N-Dihexyl-2-(4-fluorophenyl)
|
5mg/瓶
|
SIGMA
|
D9542-10MG
|
DAPI
|
10mg
|
SIGMA
|
D9785-10L
|
DMEM/Nutrient
Mixture F-12 Ham
|
10L
|
SIGMA
|
DN25-100MG
|
脱氧核糖核酸酶
|
100mg
|
SIGMA
|
DN25-10MG
|
脱氧核糖核酸酶
I 来源于牛胰腺
|
10mg/瓶
|
SIGMA
|
E003256-25G
|
L-(+)-阿拉伯糖
|
25G
|
SIGMA
|
E10521-10G
|
3-氨基苯甲酸乙酯
|
10g
|
SIGMA
|
E2888-100ML
|
Earle
平衡盐
|
100ml
|
SIGMA
|
E6511-100G
|
Ethylenediaminetetraacetic
acid tetrasodium salt dihydrate
|
100G
|
SIGMA
|
E7885-1MG
|
弹性蛋白酶
|
1mg
|
SIGMA
|
E7885-5MG
|
弹性蛋白酶
来源于猪胰腺
|
5mg
|
SIGMA
|
F2637-10G
|
Ficoll
400
|
10g
|
SIGMA
|
F2637-5G
|
Ficoll
400
|
5g
|
SIGMA
|
F3879-250MG
|
Fibrinogen
来源于人类血浆
|
250mg/瓶
|
SIGMA
|
F4375-10G
|
Ficoll
PM 400
|
10g
|
SIGMA
|
F5259-2ML
|
Anti-Human
IgA (α-chain specific)−FITC antibody produced in goat
|
2ml
|
SIGMA
|
F8129-25G
|
Acid
Fuchsin
|
25g
|
SIGMA
|
G1514-100G
|
D-(+)-葡萄糖胺
盐酸盐
|
100g
|
SIGMA
|
G5388-500G
|
Galactose
|
500g
|
SIGMA
|
G7021-1KG
|
D-(+)-葡萄糖
|
1KG
|
SIGMA
|
G7422-200UL
|
Anti-GSDMD
(126-138) antibody
|
200ul
|
SIGMA
|
G9422-10G
|
β-甘油磷酸
|
10g
|
SIGMA
|
G9422-50G
|
β-Glycerophosphate
disodium salt hydrate
|
50g
|
SIGMA
|
G9652-1MG
|
GMI
|
1mg
|
SIGMA
|
GBL654002-100EA
|
Grace
Bio-Labs SecureSeal imaging spacer
|
100EA
|
SIGMA
|
H3136-100G
|
Hematoxylin
|
100g
|
SIGMA
|
H3375-250G
|
HEPES
|
250G/瓶
|
SIGMA
|
H3506-100MG
|
透明质酸酶
来源于牛睾丸
|
100mg/瓶
|
SIGMA
|
H8627-1G
|
羟基脲
|
1G
|
SIGMA
|
HT254-250ML
|
Van
Gieson Solution Acid Fuchsin
|
250ml
|
SIGMA
|
I0516-5ML
|
Insulin
solution
|
5ml
|
SIGMA
|
I202-100G
|
咪唑
|
|
SIGMA
|
I3021-100ML
|
IGEPAL
CA-630
|
100G
|
SIGMA
|
I4131-10MG
|
IgG来源大鼠血清
|
10mg/支
|
SIGMA
|
I5500-100MG
|
Insulin
from bovine pancreas
|
100mg/瓶
|
SIGMA
|
L1375-100ML
|
DL-乳酸钠
溶液
|
|
SIGMA
|
L1418-200UL
|
Anti-LAMP1
antibody produced in rabbit
|
200ul
|
SIGMA
|
L2884-1MG
|
亮抑酶肽
|
1mg/瓶
|
SIGMA
|
L4391-1MG
|
Lipopolysaccharides
|
1mg
|
SIGMA
|
L6146-1L
|
Lugol
溶液
|
1L
|
SIGMA
|
M0199-5MG
|
Mdivi-1
|
5mg/瓶
|
SIGMA
|
M0375-100G
|
马来酸
|
100g
|
SIGMA
|
M0375-500G
|
马来酸
|
500g
|
SIGMA
|
M2128-1G
|
噻唑蓝MTT
|
1g
|
SIGMA
|
M3148-25ML
|
2-巯基乙醇
|
25ml
|
SIGMA
|
M4403-0.2ml
|
Monoclonal
Anti-MAP2 antibody produced in mouse
|
|
SIGMA
|
M5655-500MG
|
噻唑蓝
|
500mg/支
|
SIGMA
|
M5939-5MG
|
(R)-N4-Hydroxy-N1-[(S)-2-(1H-i
|
5mg/瓶
|
SIGMA
|
M6250-250ML
|
2-Mercaptoethanol
(2ME)
|
250ml
|
SIGMA
|
M7145-100ML
|
非必需氨基酸溶液
|
100ml/瓶
|
SIGMA
|
M8046-1G
|
Mifepristone
|
1g/瓶
|
SIGMA
|
M8883-250MG
|
4-甲基伞形酮磷酸酯
|
250mg/瓶
|
SIGMA
|
MAK104-1KT
|
Total
Carbohydrate Assay Kit
|
1kit
|
SIGMA
|
MAK316-1KT
|
亚铁血红素检测试剂盒
|
1KT
|
SIGMA
|
MINI26-1KT
|
PKH26
Red Fluorescent Cell Linker Mini Kit
|
1kit
|
SIGMA
|
N7143-10MG
|
Nigericin
sodium salt
|
10mg
|
SIGMA
|
P-4265
|
Pepstatin
A
|
100
mg
|
SIGMA
|
P1379-1L
|
Tween
20
|
1L/瓶
|
SIGMA
|
P1644-500ML
|
Percoll
|
500ml
|
SIGMA
|
P2636-100MG
|
Poly-L-lysine
hydrobromide
|
100mg
|
SIGMA
|
P3803-100ML
|
Phenol/Chloroform/Isoamyl
alco
|
100ml/瓶
|
SIGMA
|
P4056-50UG
|
Platelet-Derived
Growth Factor
|
50ug/支
|
SIGMA
|
P4543-25G
|
丙戊酸
钠盐
|
25g/瓶
|
SIGMA
|
P5515-1MG
|
Prostaglandin
E1
|
1mg
|
SIGMA
|
P5976-1MG
|
Anti-Platelet-Derived
Growth F
|
1mg/支
|
SIGMA
|
P6148-500G
|
Paraformaldehyde
|
500g
|
SIGMA
|
P6188-1MG
|
Prostaglandin
I2 sodium salt
|
1mg
|
SIGMA
|
P8139-1MG
|
Phorbol
12-myristate 13-acetate
|
1mg
|
SIGMA
|
P8340-1ML
|
Protease
Inhibitor Cocktail
|
1ml
|
SIGMA
|
P8825-.2ML
|
Anti-Proliferating
Cell Nuclea
|
0.2ml/支
|
SIGMA
|
P8833-25MG
|
Puromycin
dihydrochloride
|
25mg
|
SIGMA
|
P9767-5G
|
棕榈酸钠
|
5g/支
|
SIGMA
|
PHR1237-500MG
|
Cholecalciferol
(Vitamin D3)
|
500mg
|
SIGMA
|
PVP360-100G
|
聚乙烯吡咯烷酮
|
100g
|
SIGMA
|
PVP360-500G
|
聚乙烯吡咯烷酮
|
500g
|
SIGMA
|
RTC000068-1L
|
Sodium
Azide 0.05% Solution
|
1L
|
SIGMA
|
S-6422
|
Na4P2O7×10H20
(NaPPi)
|
500G
|
SIGMA
|
S0130-1G
|
链脲佐菌素
|
1g
|
SIGMA
|
S0192-500ML
|
Hematopoietic
Stem Cell Expansion Medium
|
500ml
|
SIGMA
|
S0192-6X500ML
|
Stemline
II Hematopoietic Stem Cell Expansion Medium
|
1PK
|
SIGMA
|
S2626-1G
|
亚精胺
|
1g
|
SIGMA
|
S4641-1KG
|
柠檬酸钠
二水合物
|
1kg/瓶
|
SIGMA
|
S607-5G
|
水杨羟肟酸
|
5G
|
SIGMA
|
S6506-5G
|
Silver
nitrate
|
5g
|
SIGMA
|
S7907-500G
|
磷酸钠
二元
|
500g
|
SIGMA
|
S8032-25G
|
Sodium
azide
|
25g
|
SIGMA
|
S8636-100ML
|
Sodium
pyruvate solution
|
100ml
|
SIGMA
|
S9133-1MG
|
亚硒酸钠
|
1mg
|
SIGMA
|
S9637-100G
|
丁二酸钠
二元 六水合物
|
100G
|
SIGMA
|
SAB4200071-200UL
|
ANTI-FLAG
antibody, Rat monocl
|
200ul/支
|
SIGMA
|
SAB4200085-200UL
|
Monoclonal
Anti-AGO2 antibody
|
200ul/支
|
SIGMA
|
SAB4200539-200UL
|
Anti-Myocardin
antibody produc
|
200ul/支
|
SIGMA
|
SML0286-25MG
|
BMS753
|
|
SIGMA
|
SML0429-5MG
|
Ac-YVAD-cmk
|
5mg
|
SIGMA
|
SML0737-25MG
|
MitoTEMPO
|
25mg
|
SIGMA
|
SML0737-5MG
|
MitoTEMPO
|
5mg
|
SIGMA
|
SRP0221-20UG
|
PTPIA2
Active human
|
20ug
|
SIGMA
|
T0665-1G
|
holo-Transferrin
human
|
|
SIGMA
|
T0665-50MG
|
holo-Transferrin
|
50mg
|
SIGMA
|
T1077-10UG
|
Tissue
Inhibitor of Metalloproteinase-2 人
|
10ug
|
SIGMA
|
T4049-100ML
|
胰蛋白酶-EDTA
溶液
|
100ml
|
SIGMA
|
T4049-500ML
|
胰蛋白酶-EDTA
溶液
|
500ml
|
SIGMA
|
T4393-100UN
|
凝血酶
来源于人类血浆
|
100un
|
SIGMA
|
T4424-100ML
|
Trypsin
solution from porcine pancreas
|
100ml
|
SIGMA
|
T4424-500ML
|
Trypsin
solution from porcine pancreas
|
500ml
|
SIGMA
|
T48402-5G
|
2,2,2-三溴乙醇
|
5g/瓶
|
SIGMA
|
T4952-5MG
|
Tanshinone
IIA
|
5mg
|
SIGMA
|
T5168-100UL
|
Monoclonal
Anti-α-Tubulin antibody produced in mouse
|
100ul
|
SIGMA
|
T5941-100G
|
Trizma
盐酸盐
|
100g
|
SIGMA
|
T5941-500G
|
Trizma
盐酸盐
|
500g
|
SIGMA
|
T6522-25MG
|
胰蛋白酶抑制剂
|
25mg
|
SIGMA
|
T7009-100UN
|
凝血酶
来源于人类血浆
|
100un
|
SIGMA
|
T7009-1KU
|
凝血酶
|
1ku
|
SIGMA
|
T8203-100UL
|
Anti-α-Tubulin
antibody
|
100ul/支
|
SIGMA
|
T8787-50ML
|
Triton
X-100
|
50ml
|
SIGMA
|
T9284-100ML
|
Triton
X-100
|
100ml
|
SIGMA
|
T9531-5G
|
D-(+)-海藻糖
二水合物
|
5g/瓶
|
SIGMA
|
U120-1MG
|
U0126
monoethanolate
|
1mg/瓶
|
SIGMA
|
V900019-500G
|
柠檬酸
|
500g
|
SIGMA
|
V900058-500G
|
Sodium
chloride
|
500g
|
SIGMA
|
V900061-500G
|
Sodium
phosphate dibasic
|
500g
|
SIGMA
|
V900068-500G
|
Potassium
chloride
|
500g
|
SIGMA
|
V900095-500G
|
柠檬酸钠
|
500g
|
SIGMA
|
V900116-500G
|
蔗糖
|
500g
|
SIGMA
|
V900144-500G
|
甘氨酸
|
500g
|
SIGMA
|
V900408-100G
|
L-谷氨酸
|
100G
|
SIGMA
|
V900477-100G
|
HEPES
|
100g
|
SIGMA
|
V900483-500G
|
Trizma碱
|
500g
|
SIGMA
|
V900510-100G
|
琼脂糖
|
100g/瓶
|
SIGMA
|
V900548-500ML
|
TWEEN
20
|
500ml
|
SIGMA
|
V900853-25ML
|
TEMED
|
25ml
|
SIGMA
|
V900859-500G
|
十二烷基硫酸钠
|
500g
|
SIGMA
|
V900883-25G
|
过硫酸铵(AP)
|
25g
|
SIGMA
|
V900930-1MG
|
雷帕霉素
|
1mg
|
SIGMA
|
Y1625-250G
|
Yeast
Extract
|
250g
|