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Recombinant Mouse IL-4(Cat. No.:CK15)

Recombinant Mouse IL-4(Cat. No.:CK15)

Recombinant Mouse Interleukin-4 is produced by our E.coli expression system and the target gene encoding His23-Ser140 is expressed.

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商品描述

Recombinant Mouse Interleukin-4 is produced by our E.coli expression system and the target gene encoding His23-Ser140 is expressed.

产品描述
Recombinant Mouse Interleukin-4 is produced by our E.coli expression system and the target gene encoding His23-Ser140 is expressed.
蛋白编号
P07750
产品别称
Interleukin-4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; IGG1 induction factor; Lymphocyte stimulatory factor 1; IL-4; BSF-1
分子量
13.4 KDa
表观分子量
14 KDa, reducing conditions
剂型描述
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, 5% Trehalose, pH 6.5.
内毒素
Less than 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
纯度
Greater than 95% as determined by reducing SDS-PAGE.
生物活性
Measured in a cell proliferation assay using M-NFS-60 mouse lymphoblast cells.  The ED50 for this effect is 0.01 ng/ml.
复溶

  • Always centrifuge tubes before opening.Do not mix by vortex or pipetting.

  • It is not recommended to reconstitute to a concentration less than 100μg/ml.

  • Dissolve the lyophilized protein in distilled water.

  • Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 

保存条件

  • Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.

  • Reconstituted protein solution can be stored at 4-7°C for 2-7 days.

  • Aliquots of reconstituted samples are stable at < -20°C for 3 months.

运输条件

  • The product is shipped at ambient temperature.

  • Upon receipt, store it immediately at the temperature listed below.

产品背景
Mouse Interleukin-4(IL-4) is a monomeric, Th2 cytokine that shows pleiotropic effects during immune responses. It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four α­helix structure. IL­4 exerts its effects through two receptor complexes, Participates in at least several B-cell activation processes as well as of other cell types. IL­4 is primarily expressed by Th2­biased CD4+T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG1 and IgE in mouse B cells, acquisition of the Th2 phenotype by naïve CD4+T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL­4 plays a dominant role in the development of allergic inflammation and asthma. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
仅供科研或生产使用，不可直接应用于人体。