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首页 ∷ 试剂 ∷ 近岸蛋白 ∷ Recombinant SARS-CoV-2 S Protein RBD (C-6His) V2(Cat. No.:DRA72)
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Recombinant SARS-CoV-2 S Protein RBD (C-6His) V2(Cat. No.:DRA72)

Recombinant SARS-CoV-2 S Protein RBD (C-6His) V2(Cat. No.:DRA72)

Recombinant SARS-CoV-2 S protein RBD Protein is produced by our Mammalian expression system and the target gene encoding Arg319-Phe541 is expressed with a 6His tag at the C-terminus.

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商品描述

Recombinant SARS-CoV-2 S protein RBD Protein is produced by our Mammalian expression system and the target gene encoding Arg319-Phe541 is expressed with a 6His tag at the C-terminus.

产品描述
Recombinant SARS-CoV-2 S protein RBD Protein is produced by our Mammalian expression system and the target gene encoding Arg319-Phe541 is expressed with a 6His tag at the C-terminus.
蛋白编号
QHD43416.1
产品别称
2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein
分子量
25.9kDa
表观分子量
35kDa, reducing conditions
剂型描述
Supplied as a 0.2 μm filtered solution of PBS, pH 7.4
纯度
Greater than 95% as determined by reducing SDS-PAGE.
生物活性
Loaded Human ACE-2-Fc(Cat#C05Y) on Protein A Biosensor, can bind 2019-nCoV S Protein RBD-His(Cat#DRA72) with an affinity constant of 4.1 nM as determined in BLI assay.
Loaded Anti-2019-nCoV S1 mAb-Fc(Cat#NC025) on Protein A Biosensor, can bind 2019-nCoV S Protein RBD-His(Cat#DRA72) with an affinity constant of 8.2 nM as determined in BLI assay.
Loaded Anti-2019-nCoV S-hIgG1 Neutralizing Antibody (8A5)-Fc(Cat#DA034) on HIS1K Biosensor, can bind 2019-nCoV S Protein RBD V2-His(Cat#DRA72) with an affinity constant of 29.71 nM as determined in BLI assay. 
保存条件
Reconstituted protein solution should be stored at ≤ -20°C.
产品背景
The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.Some findings indicated that the mutated viruses may be evolved to acquire remarkably increased infectivity.
仅供科研或生产使用，不可直接应用于人体。