English 简体中文
产品
文章
搜索
搜索
首页 ∷ 试剂 ∷ 阿拉丁 ∷ C129276 卡莫他特甲磺酸盐 ,≥98%
当前位置：
C129276 卡莫他特甲磺酸盐 ,≥98%

C129276 卡莫他特甲磺酸盐 ,≥98%

0.00
0.00
  
商品描述

基本信息

产品名称卡莫他特甲磺酸盐
英文名称Camostat Mesilate
别名甲磺酸卡莫司他;FOY305
英文别名FOY305; FOY-S980; Foipan mesylate;4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate;2-(Dimethylamino)-2-oxoethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulphonate
应用A protease and Trypsin inhibitor.
规格或纯度≥98%
运输条件冰袋运输
生化机理Camostat mesylate, a protease inhibitor, has been found to cause significant increase in the bicarbonate concentration, secretory rate, and output of pancreatic juice of dogs. Furthermore it was found that this water induction and bicarbonate secretion increase was achieved via direct regulation of ductular cells of the dog pancreas. Other studies have shown Camostat mesylate to suppress spinal Fos expression in the rat, which is a marker for neuronal activation. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models. Camostat mesylate has also demonstrated the ability to prevent Trypsin attack of microspheres, which causes the degradation product N-benzoyl-dl-arginine. Camostat mesylate is an inhibitor of KLK, plasminogen, Prothrombin and Trypsin.Trypsin-like protease inhibitor. Reversibly inhibits airway epithelial sodium channel (ENaC) function (IC 50 = 50 nM). Inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes and disrupts proliferation of pancreatic st

一般描述

Camostat Mesilate是胰蛋白酶样的蛋白酶抑制剂，抑制上皮细胞钠离子通道(ENaC)功能，IC50为50 nM, 对Trypsin, Prostasin 和 Matriptase作用效果稍弱。A protease and Trypsin inhibitor.


Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.
A protease and Trypsin inhibitor.


相关属性

CAS编号59721-29-8
熔点164-168°
溶解性Soluble in water (100 mM), DMSO (100 mM), and ethanol (<1 mg/ml).
储存温度2-8°C储存
MDL号MFCD00941410
分子量494.52
分子式C20H22N4O5.CH4O3S
品牌阿拉丁
备注如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
PubChem CID5284360