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首页 ∷ 试剂 ∷ 阿拉丁 ∷ Y129399 Y-27632二盐酸盐 ,≥98%
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Y129399 Y-27632二盐酸盐 ,≥98%

Y129399 Y-27632二盐酸盐 ,≥98%

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商品描述

基本信息

产品名称Y-27632二盐酸盐
英文名称Y-27632 dihydrochloride
别名ROCK Inhibitor；(1R,4r)-4-[(R)-1-氨乙基]-N-(吡啶-4-基)环己烷甲酰胺二盐酸盐；(R)-(+)-反式-4-(1-氨基乙基)-N-(4-吡啶基)环己烷甲酰胺 二盐酸盐
英文别名(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride;ROCK Inhibitor
规格或纯度≥98%
运输条件超低温冰袋运输
生化机理Y-27632 is ROCK inhibitor, as a novel bronchodilator. Y-27632 is available with IC50 of 3.3±0.25 μM and 2.8±0.2 μM in human and rabbit tissues, respectively.Y-27632 is a research tool with a wide variety of biological effects, mainly used in the field of stem cell research for maintenance and differentiation.

一般描述

Y-27632 dihydrochloride is a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 dihydrochloride increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations sμggest that Y-27632 dihydrochloride suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats sμggest that Y-27632 dihydrochloride can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 dihydrochloride also inhibits protein kinase C related kinase, PRK2.A cell permeable inhibitor of ROCK-1 and ROCK-2


Y-27632 dihydrochloride is a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 dihydrochloride increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations suggest that Y-27632 dihydrochloride suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats suggest that Y-27632 dihydrochloride can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 dihydrochloride also inhibits protein kinase C related kinase, PRK2.
A cell permeable inhibitor of ROCK-1 and ROCK-2


相关属性

CAS编号129830-38-2
敏感性对湿度敏感；对光线敏感；对热敏感；
比旋光度+4.0° (C=1,MeOH)
熔点252 °C
溶解性Soluble in water (14 mg/mL), ethanol (~5 mg/mL), DMSO (~20 mg/mL), DMF (~30 mg/mL), PBS, pH 7.2 (~10 mg/mL), and methanol (25 mg/mL).
储存温度-20°C储存,充氩
MDL号MFCD03490488
分子量320.26
分子式C14H21N3O·2HCl
品牌阿拉丁
备注如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
法律信息Sold under license from Mitsubishi Pharma Corporation
PubChem CID9901617