CPI-455
| Description |
CPI-455 is a specific KDM5 inhibitor. |
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| IC50 & Target |
KDM5 |
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| In Vitro |
CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4 trimethylation (H3K4me3) and decreases the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents. CPI-455, with high measured affinity for the target KDM5 proteins. Within 24 hours, increases in H3K4me3, but not H3K4me2, are observed after exposure to either of the two active compounds, CPI-455 and CPI-766, in a dosedependent manner. IC50 calculation for KDM5 Inhibitor CPI0455 in 3 luminal breast cancer cell lines MCF-7, T-47 and EFM-19 are 35.4, 26.19 and 16.13 μM, respectively. |
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| Solvent & Solubility |
In Vitro:
DMSO : ≥ 34 mg/mL (122.17 mM) * "≥" means soluble, but saturation unknown.
Preparing
Stock Solutions
*Please refer to the solubility information to select the appropriate solvent.
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品牌
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货号
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名称
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规格
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MCE
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HY-100406-50MG
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(S)-MCPG
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MCE
|
HY-100421
|
CPI-455
|
5MG
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MCE
|
HY-10071-1ml
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Y-27632
|
1ml
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MCE
|
HY-10071-50mg
|
Y-27632
|
50mg
|
|
MCE
|
HY-10108
|
LY294002
|
10
mM * 1 mL
|
|
MCE
|
HY-101091-5mg
|
Importazole
|
5mg
|
|
MCE
|
HY-101391-100mg
|
Picrotoxin
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100mg
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|
MCE
|
HY-101494-1MG
|
LY3214996
|
|
|
MCE
|
HY-10182 -1ml
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CHIR-99021
|
1ml
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MCE
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HY-10219-10MG
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Rapamycin
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|
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MCE
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HY-10219-25MG
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Rapamycin
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MCE
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HY-10254-1ml
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PD0325901
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1ml
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MCE
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HY-10358
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MK
2206 dihydrochloride
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10
mM * 1 mL
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MCE
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HY-10583-1ml
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Y-27632
(dihydrochloride)
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1ml
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MCE
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HY-10627A-50mg
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GW3965
hydrochloride
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MCE
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HY-10627A-5MG
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GW3965
hydrochloride
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1mg
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HY-10997-10MG
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PCI-32765
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HY-12028
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PD98059
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10
mM * 1 mL
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MCE
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HY-12028-5MG
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PD98059
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HY-12275
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FR
180204
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10
mM * 1 mL
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1mg
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1mg
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HY-17356-10g
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HY-17382
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100MG
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G-418
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5G
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MCE
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HY-17567-100mg
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Heparin
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100mg
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MCE
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HY-17567A-100mg
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Heparin
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100mg
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HY-17589-100MG
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1g
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HY-P0035-10mg
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Insulin(human)
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10mg
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HY-P7011-10ug
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Recombinant
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10ug
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HY-P7154-10ug
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Recombinant
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传真：020-80929345