FR 180204
| Description |
FR 180204 is an ATP-competitive, selective ERK inhibitor with Ki of 0.31 μM and 0.14 μM for ERK1 and ERK2, respectively. |
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| IC50 & Target |
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| In Vitro |
In AP-1-transfected cells, FR180204 dose-dependently inhibits AP-1 transactivation with IC50 of 3.1 μM. FR 180204 inhibits spontaneous mesothelioma cell growth. |
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| In Vivo |
FR180204 (100 mg/kg, i.p., b.i.d.) significantly decreases the severity of symptoms and body weight loss in collagen-induced arthritis mice. In a mouse model of dengue virus (DENV) infection, FR180204 limits hepatocyte apoptosis, reduces DENV-induced liver injury, and improves clinical parameters. |
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| Solvent & Solubility |
In Vitro:
DMSO : ≥ 50 mg/mL (152.75 mM) * "≥" means soluble, but saturation unknown.
Preparing
Stock Solutions
*Please refer to the solubility information to select the appropriate solvent.
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品牌
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货号
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名称
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规格
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MCE
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HY-100406-50MG
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(S)-MCPG
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MCE
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HY-100421
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CPI-455
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5MG
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MCE
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HY-10071-1ml
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Y-27632
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1ml
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MCE
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HY-10071-50mg
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Y-27632
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50mg
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MCE
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HY-10108
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LY294002
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10
mM * 1 mL
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MCE
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HY-101091-5mg
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Importazole
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5mg
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HY-101391-100mg
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Picrotoxin
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100mg
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HY-101494-1MG
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LY3214996
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HY-10182 -1ml
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CHIR-99021
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1ml
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HY-10219-10MG
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Rapamycin
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HY-10219-25MG
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Rapamycin
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HY-10254-1ml
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PD0325901
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1ml
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HY-10358
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MK
2206 dihydrochloride
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10
mM * 1 mL
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HY-10583-1ml
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Y-27632
(dihydrochloride)
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1ml
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HY-10627A-50mg
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GW3965
hydrochloride
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MCE
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HY-10627A-5MG
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GW3965
hydrochloride
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HY-108709
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CC-671
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1mg
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HY-10997-10MG
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PCI-32765
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HY-12028
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PD98059
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10
mM * 1 mL
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MCE
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HY-12028-5MG
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PD98059
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HY-12275
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FR
180204
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10
mM * 1 mL
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HY-12466-1mg
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Z-DEVD-FMK
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1mg
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HY-12526
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DMOG
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50mg
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Narciclasine
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1mg
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HY-17026-100mg
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Gemcitabine
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100mg
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HY-17356-10g
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Fenofibrate
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HY-17382
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Metoclopramide
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100MG
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HY-17538-10MG
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ZLN005
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10MG
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MCE
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HY-17561-5G
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G-418
disulfate
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5G
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MCE
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HY-17567-100mg
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Heparin
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100mg
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MCE
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HY-17567A-100mg
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Heparin
sodium salt
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100mg
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HY-17589-100MG
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Chloroquine
diphosphate
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HY-18012
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AVL-292
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10MG
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HY-19312-50mg
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3-Methyladenine
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5g
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100mg
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HY-N0583
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1g
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MCE
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HY-P0035-10mg
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Insulin(human)
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10mg
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MCE
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HY-P7011-10ug
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Recombinant
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10ug
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MCE
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HY-P7154-10ug
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Recombinant
Mouse DKK-1 (CHO-expressed)
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10ug
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