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DMOG

DMOG

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商品描述
DMOG,HY-15893 ,MCE:
Description

DMOG (Dimethyloxallyl Glycine) is a cell-permeable and competitive inhibitor of HIF-1α prolyl hydroxylase (HIF-PH).

IC50 & Target

HIF-1α prolyl hydroxylase

In Vitro

DMOG efficiently suppresses hydroxyproline synthesis in intact cells, but shows only weakly active in the microsomal system. DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC.

In Vivo

DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 101.5 mg/mL (579.54 mM)

H2O : 50 mg/mL (285.49 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7097 mL 28.5486 mL 57.0972 mL
5 mM 1.1419 mL 5.7097 mL 11.4194 mL
10 mM 0.5710 mL 2.8549 mL 5.7097 mL
*Please refer to the solubility information to select the appropriate solvent.

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