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Metoclopramide

Metoclopramide

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商品描述
Metoclopramide,HY-17382,MCE:
Description

Metoclopramide is a dopamine D2 antagonist that is used as an antiemetic. IC50 Value: Target: D2 Receptor Metoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is the antiemetic drug of choice in pregnant women. Findings provide reassurance regarding the safety of metoclopramide for the fetus when the drug is given to women to relieve nausea and vomiting during pregnancy. Evidence also supports its use for gastroparesis (poor stomach emptying) and gastroesophageal reflux disease. It appears to bind to dopamine D2 receptors where it is a receptor antagonist, and is also a mixed 5-HT3 receptor antagonist/ 5-HT4 receptor agonist.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT02979548 Dr Atul Sharma|All India Institute of Medical Sciences, New Delhi Chemotherapy Induced Vomiting|Acute Myeloid Leukemia November 2016 Phase 3
NCT00003213 Swiss Group for Clinical Cancer Research Nausea and Vomiting|Unspecified Adult Solid Tumor, Protocol Specific May 1996 Phase 3
NCT00632606 Women and Infants Hospital of Rhode Island Headache August 2008 Phase 2|Phase 3
NCT02295280 St. Louis University Headache January 2012 Not Applicable
NCT01191645 Region Örebro County Opioid Induced Pharyngeal and Esophageal Dysfunction October 2010 Phase 4
NCT01630109 Genesys Regional Medical Center Pill Capsule Endoscopy Completion Rates December 2012 Phase 4
NCT03383315 University of Malaya Trauma|Opioid Analgesic Adverse Reaction July 1, 2017 Phase 2
NCT00275184 London North West Healthcare NHS Trust Small Bowel Disease|Gastrointestinal Hemorrhage|Refractory Anemia January 2006 Phase 3
NCT02784392 Lyric Pharmaceuticals Enteral Feeding Intolerance (EFI) October 2016 Phase 2
NCT01984931 CM Chungmu Hospital|Korea United Pharm. Inc. Nausea|Vomiting October 2013 Phase 3
NCT02253524 Pamukkale University Nausea|Vomiting|Vertigo November 2012 Phase 4
NCT01858090 Baskent University Elective Caesarean Section Surgeries January 2009 Phase 3
NCT00120653 National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Myelodysplastic Syndromes July 14, 2005 Phase 2
NCT03056352 Montefiore Medical Center Post-Traumatic Headache March 1, 2017 Phase 1|Phase 2
NCT03331965 Duke University Radiation Exposure|Enteral Nutrition April 9, 2018 Phase 2
NCT01825941 Montefiore Medical Center Migraine April 2013 Phase 4
NCT03588338 Adnan Menderes University Postoperative Nausea and Vomiting July 20, 2018 Phase 4
NCT01406860 University of Iowa Primary Headaches (Includes Migraines, Tension, Cluster Headaches) July 2011 Not Applicable
NCT02481219 Medtronic - MITG Colorectal Cancer Screening May 2015 Not Applicable
NCT00477776 National University Hospital, Singapore|The University of Western Australia Breastfeeding April 2006 Phase 3
NCT00237705 Vancouver General Hospital Post Concussive Headache|Post Concussive Syndrome May 2004 Not Applicable
NCT01636947 Merck Sharp & Dohme Corp. Nausea|Vomiting December 12, 2012 Phase 4
NCT01148264 Karin Jordan|Martin-Luther-Universität Halle-Wittenberg Emesis July 2010 Phase 2
NCT00655642 Vanderbilt University Nausea March 2007 Not Applicable
NCT00845858 Evoke Pharma Gastroparesis|Diabetic Gastroparesis|Diabetes|Diabetes Mellitus|Delayed Gastric Emptying April 2009 Phase 2
NCT02847494 Montefiore Medical Center Migraine September 1, 2016 Phase 4
NCT02163434 University at Buffalo|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Hyperemesis Gravidarum June 2014 Phase 3
NCT02025751 Evoke Pharma Diabetic Gastroparesis April 2014 Phase 3
NCT02441673 Lagos State Health Service Commission Post Anaesthetic Shivering October 12, 2018 Phase 2
NCT02965963 University of Alberta|Natural Sciences and Engineering Research Council, Canada Health December 2016 Not Applicable
NCT02972502 OhioHealth Headache, Migraine February 2014 Phase 4
NCT01837394 Jens Borglum Neimann|Bispebjerg Hospital Postoperative Pain|Postoperative Nausea and Vomiting|Postoperative Function Level August 2012 Phase 4
NCT01631994 Winthrop University Hospital Gastric Transit Time September 2011 Not Applicable
NCT03220958 Montefiore Medical Center Post-Traumatic Headache August 1, 2017 Phase 3
NCT02681211 University of Louisville Migraine Headache February 2016 Not Applicable
NCT01093690 Mahidol University|Siriraj Hospital Cancer April 2009 Not Applicable
NCT01289938 Matthias Schwab|University Hospital Tuebingen Drug Metabolism, Poor, CYP2D6-RELATED July 2009 Phase 1
NCT02959840 Rutgers, The State University of New Jersey Nausea|Vomiting|Satisfaction July 2015 Phase 4
NCT03649009 Universiti Kebangsaan Malaysia Medical Centre Hyperlactatemia January 1, 2018 Not Applicable
NCT00355394 Children´s Hospital of Philadelphia Migrainous Headache August 2006 Phase 2
NCT02913469 General Hospital of Chinese Armed Police Forces ST-segment Elevation Myocardial Infarction December 2014 Phase 4
NCT02619201 Hospital General Naval de Alta Especialidad - Escuela Medico Naval Acute Gastroenteritis|Vomiting November 2015 Phase 3
NCT02314351 Kocaeli University Migraine Disorders December 2014 Phase 4
NCT00581477 Vanderbilt University|Vanderbilt University Medical Center Autonomic Nervous System Diseases|Orthostatic Hypotension|Dopamine Beta-Hydroxylase Deficiency|Orthostatic Intolerance January 2004 Phase 3
NCT01267864 Montefiore Medical Center Acute Migraine November 2010 Phase 4
NCT01069536 Pamukkale University Akathisia|Nausea March 2007 Not Applicable
NCT02625181 Vanderbilt University|University of Washington|Vanderbilt University Medical Center Postoperative Nausea and Vomiting July 2016 Not Applicable
NCT00264719 National University Hospital, Singapore Breastfeeding January 2006 Not Applicable
NCT03477903 Millennium Pharmaceuticals, Inc.|Takeda Critical Illness|Enteral Nutrition|Enteral Feeding Intolerance August 25, 2018 Phase 2
NCT00395161 Michael Dean|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Seattle Children´s Hospital|Children´s Hospital Los Angeles|Arkansas Children´s Hospital Research Institute|Children´s Hospital of Michigan|University of Pittsburgh|Children´s Research Institute|University of California, Los Angeles|Harborview Injury Prevention and Research Center|University of Utah Sepsis April 2007 Phase 3
NCT02410460 Mercy Facial Plastic Surgery Center Rhytidoplasty September 2013 Not Applicable
NCT01522326 Massachusetts General Hospital Acute Mountain Sickness|High Altitude Headache March 2012 Not Applicable
NCT02135510 VU University Medical Center|Noordwest Ziekenhuisgroep|Rijnstate|Tergooiziekenhuizen locatie Hilversum|Ziekenhuis Amstelland Solid Tumors June 2013 Phase 3
NCT01781377 G. d´Annunzio University|Azienda Ospedaliera San Gerardo di Monza PREGNANCY February 2008 Phase 4
NCT01216410 Duke University|IWK Health Centre Cesarean Delivery December 2008 Not Applicable
NCT00242450 Lawson Health Research Institute Infant, Premature March 2002 Phase 4
NCT02262923 Mount Sinai Hospital, Canada in Vitro Fertilization|Poor Responder March 2016 Not Applicable
NCT00778011 WellSpan Health Nausea|Vomiting November 2005 Phase 4
NCT01165866 Hamad Medical Corporation Gastroenteritis June 2008 Phase 4
NCT03017391 Radboud University Nausea|Vomiting|Cancer January 2017 Phase 4
NCT02627950 University of Luebeck Acute Myocardial Infarction December 2015 Phase 4
NCT00557544 IRCCS Burlo Garofolo Migraine June 2009 Phase 3
NCT01937234 Ain Shams University|Armed Forces Hospitals, Southern Region, Saudi Arabia Prolonged First Stage of Labor July 2013 Phase 4
NCT02098499 United States Naval Medical Center, Portsmouth Migraine Headaches|Nausea|Restlessness June 2013 Phase 4
NCT00869310 S. Maria Hospital, Terni Emesis September 2009 Phase 3
NCT02098915 The Hospital for Sick Children|The Physicians´ Services Incorporated Foundation Gastroschisis March 2014 Phase 3
NCT03081416 Brooke Army Medical Center Headache|Intranasal Ketamine May 2016 Phase 3
NCT03698292 Ain Shams University Critically-ill Patients October 2018 Not Applicable
NCT00475306 Montefiore Medical Center Nausea|Extrapyramidal Symptoms May 2007 Phase 4
NCT01953081 Theravance Biopharma Enteral Feeding Intolerance January 2014 Phase 1|Phase 2
NCT02466984 University Hospital, Bordeaux Nausea|Vomiting July 2016 Phase 3
NCT01596166 University of Alberta|Canadian Institutes of Health Research (CIHR) Probable Migraine|Migraine With Aura|Migraine Without Aura February 2012 Phase 4
NCT03269435 Montefiore Medical Center Migraine November 1, 2017 Phase 4
NCT02907632 Nathalie Charpak|Hospital Universitario San Ignacio|Pontificia Universidad Javeriana|Kangaroo Foundation Gastroesophageal Reflux June 1, 2017 Phase 4
NCT03560583 Barzilai Medical Center Poor Responders in IVF July 2018 Not Applicable
NCT02222220 Beersheva Mental Health Center|Tirat Carmel Mental Health Center Clozapine-induced Hypersalivation January 2012 Phase 3
NCT00364806 Montefiore Medical Center|Albert Einstein College of Medicine, Inc. Migraine August 2006 Phase 4
NCT01934192 GlaxoSmithKline Gastroparesis April 4, 2014 Phase 2
NCT02025725 Evoke Pharma Diabetic Gastroparesis April 2014 Phase 3
NCT01011673 Montefiore Medical Center Headache November 2009 Phase 4
NCT00008736 National Center for Research Resources (NCRR)|Children´s Hospital of Philadelphia Infant, Newborn, Diseases Phase 2
NCT00682734 Montefiore Medical Center Migraine April 2008 Phase 3
Solvent & Solubility
In Vitro: 

DMSO : ≥ 41 mg/mL (136.76 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 3.3356 mL 16.6778 mL 33.3556 mL
5 mM 0.6671 mL 3.3356 mL 6.6711 mL
10 mM 0.3336 mL 1.6678 mL 3.3356 mL
*Please refer to the solubility information to select the appropriate solvent.

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