FRAX1036，HY-19538，MCE

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FRAX1036

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商品描述

FRAX1036，HY-19538，MCE:

Description

FRAX1036 is a PAK inhibitor with K_is of 23.3 nM, 72.4 nM, and 2.4 μM for PAK1, PAK2 and PAK4, respectively.

IC₅₀ & Target

PAK1

23.3 nM (Ki)

PAK2

72.4 nM (Ki)

PAK4

2.4 μM (Ki)

In Vitro

FRAX1036 is a PAK inhibitor with K_is of 23.3 nM, 72.4 nM, and 2.4 μM for PAK1, PAK2 and PAK4, respectively. FRAX1036 (2.5 μM) incombination with docetaxel alters stathmin phosphorylation, induces the apoptotic marker cleaved PARP and increases kinetics of apoptosis in MDA-MB-175 and HCC2911 cells; also alters microtubule organization, mitosis and cell fate in U2OS cells. Moreover, FRAX1036 shows significantly effective inhibition on U2OS cells. FRAX1036 (10 μM) affects the proliferation of non-small cell lung cancer (NSCLC) cells when added to KRAS prenylation inhibitors.

Solvent & Solubility
In Vitro:

DMSO : 5.3 mg/mL (10.23 mM; Need warming)

Preparing
Stock Solutions

Concentration Solvent Mass 1 mg 5 mg 10 mg

1 mM 1.9303 mL 9.6516 mL 19.3032 mL

5 mM 0.3861 mL 1.9303 mL 3.8606 mL

10 mM 0.1930 mL 0.9652 mL 1.9303 mL

*Please refer to the solubility information to select the appropriate solvent.

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品牌	货号	名称	规格
MCE	HY-100406-50MG	(S)-MCPG
MCE	HY-100421	CPI-455	5MG
MCE	HY-10071-1ml	Y-27632	1ml
MCE	HY-10071-50mg	Y-27632	50mg
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MCE	HY-101091-5mg	Importazole	5mg
MCE	HY-101391-100mg	Picrotoxin	100mg
MCE	HY-101494-1MG	LY3214996
MCE	HY-10182 -1ml	CHIR-99021	1ml
MCE	HY-10219-10MG	Rapamycin
MCE	HY-10219-25MG	Rapamycin
MCE	HY-10254-1ml	PD0325901	1ml
MCE	HY-10358	MK 2206 dihydrochloride	10 mM * 1 mL
MCE	HY-10583-1ml	Y-27632 (dihydrochloride)	1ml
MCE	HY-10627A-50mg	GW3965 hydrochloride
MCE	HY-10627A-5MG	GW3965 hydrochloride
MCE	HY-108709 -1mg	CC-671	1mg
MCE	HY-10997-10MG	PCI-32765
MCE	HY-12028	PD98059	10 mM * 1 mL
MCE	HY-12028-5MG	PD98059
MCE	HY-12275	FR 180204	10 mM * 1 mL
MCE	HY-12466-1mg	Z-DEVD-FMK	1mg
MCE	HY-12526	Tetrodotoxin	1MG
MCE	HY-13315-50MG	Montelukast sodium	50MG
MCE	HY-13316	Mitomycin C	5MG
MCE	HY-13688A-10MG	PJ34
MCE	HY-14166-100MG	MK-886
MCE	HY-15310-500mg	Ivermectin	500mg
MCE	HY-15893-50mg	DMOG	50mg
MCE	HY-16563-1mg	Narciclasine	1mg
MCE	HY-17026-100mg	Gemcitabine	100mg
MCE	HY-17356-10g	Fenofibrate
MCE	HY-17382	Metoclopramide	100MG
MCE	HY-17538-10MG	ZLN005	10MG
MCE	HY-17561-5G	G-418 disulfate	5G
MCE	HY-17567-100mg	Heparin	100mg
MCE	HY-17567A-100mg	Heparin sodium salt	100mg
MCE	HY-17589-100MG	Chloroquine diphosphate
MCE	HY-18012	AVL-292	10MG
MCE	HY-19312-500MG	3-Methyladenine
MCE	HY-19312-50mg	3-Methyladenine	50mg
MCE	HY-19538-1mg	FRAX1036	1mg
MCE	HY-50846-2MG	SCH772984
MCE	HY-50907-1ml	ABT-737	1ml
MCE	HY-66009-1ml	Epalrestat	1ml
MCE	HY-B0089	Acarbose	200MG
MCE	HY-B0141-1G	Estradiol	1g
MCE	HY-B0795-5MG	MHY1485
MCE	HY-B0919-1ml	Azaserine	1ml
MCE	HY-B1041-1ml	Aminoguanidine hydrochloride	1ml
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MCE	HY-B1756-5g	Rotenone	5g
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MCE	HY-P7154-10ug	Recombinant Mouse DKK-1 (CHO-expressed)	10ug