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Estradiol

Estradiol

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商品描述
Estradiol,HY-B0141,MCE:
Description

Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Estradiol causes new dendritic spines and synapses in hippocampal CA1 pyramidal cells. Estradiol increases NMDA receptor binding by 46% in parallel with dendritic spine and synapse density. Estradiol also elevates sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input and such an effect is correlated with the estradiol-induced increase in dendritic spine density in the apical dendritic tree of these cells. Estradiol reduces Ba2+ entry reversibly via Ca2+ channels in acutely dissociated and cultured neostriatal neurons. Estradiol also reduces Ba2+ currents but is significantly less effective than Estradiol in rat neostriatal neurons. Estradiol dose-dependently inhibits IL-1-, TNF-, and IL-1 and TNF-induced production of bioassayable IL-6. Estradiol blocks TNF-induced IL-6 production and osteoclast development in primary bone cell cultures derived from neonatal murine calvaria.

In Vivo

Estradiol functions in hippocampal synapse density during the estrous cycle in the adult rat. Estradiol reverses the ovariectomy-induced decrease in spine density. Estradiol in combination with progesterone enhances spine density for 2 to 6 h but decreases following estradiol alone.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT00932321 Warner Chilcott Prevention of Pregnancy January 2004 Phase 3
NCT02845388 Omar Ahmed El Sayed Saad|Ain Shams Maternity Hospital Infertility September 2015 Phase 2
NCT00184795 Novo Nordisk A+S Menopause|Menopausal Vasomotor Symptoms May 28, 2004 Phase 3
NCT01895881 Rush University Medical Center Cerebral Aneurysm|Menopause|Treatment April 2013 Phase 2
NCT00204438 University of Saskatchewan|Canadian Institutes of Health Research (CIHR) Contraception February 2002 Not Applicable
NCT03018366 Cedars-Sinai Medical Center Estrogen Deficiency|Cardiovascular Disease (CVD)|Hypothalamic Amenorrhea January 2017 Phase 2
NCT00338052 Warner Chilcott Contraception June 2006 Phase 2
NCT00722800 Massachusetts General Hospital|Bayer Hidradenitis Suppurativa October 2008 Phase 2
NCT00554632 University of Vermont|University of Vermont Medical Center Venous Thrombosis April 2003 Not Applicable
NCT00640224 Silva Arslanian|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|University of Pittsburgh Polycystic Ovary Syndrome March 2005 Phase 4
NCT00909857 Bayer Primary Dysmenorrhea April 2009 Phase 3
NCT02330757 Mansoura University Infertility January 2015 Phase 4
NCT01076621 Novo Nordisk A+S Menopause|Postmenopausal Bleeding May 2010
NCT02255396 University Hospital, Clermont-Ferrand Non-obstructive Azoospermia With Testicular Biopsy for Spermatozoa Extraction January 2009
NCT00361075 Northwestern University|University of Washington Menopause|Postmenopause|Premenopause|Cardiovascular Disease July 1998 Phase 4
NCT01597986 Astellas Pharma Global Development, Inc.|Basilea Pharmaceutica International Ltd|Astellas Pharma Inc Pharmacokinetics of Isavuconazole|Pharmacokinetics of Ethinyl Estradiol and Norethindrone|Healthy Volunteers April 2012 Phase 1
NCT02272647 Mayo Clinic Healthy December 2014 Phase 1
NCT00999479 University of Oklahoma Endometrioma October 2009 Not Applicable
NCT01448291 Eastern Virginia Medical School|Merck Sharp & Dohme Corp. Vaginosis, Bacterial October 2011 Phase 4
NCT03332303 Prasco LLC Vulvar and Vaginal Atrophy October 18, 2017 Phase 3
NCT02638922 Rigshospitalet, Denmark Constitutional Tall Stature January 2014
NCT03329898 Beijing Obstetrics and Gynecology Hospital Intrauterine Adhesion October 31, 2017 Not Applicable
NCT01209143 Genentech, Inc. Solid Cancers November 2010 Phase 1
NCT02210702 The Jones Institute Postpartum Depressive Mood|Postpartum Sexual Function July 2014 Phase 4
NCT01023178 Stanford University Ovarian Failure, Premature February 2007 Not Applicable
NCT00307632 Janssen-Cilag Farmaceutica Ltda. Contraception February 2003 Phase 4
NCT01083641 University of Wisconsin, Madison Female Breast Cancer January 2010 Phase 2
NCT01569945 University Hospital, Gasthuisberg Subfertility September 2004 Not Applicable
NCT01928082 University of Chicago Hypercalciuria|Hypercalciuria, Familial Idiopathic|Osteopenia|Osteoporosis August 1, 2013 Phase 2
NCT01301183 Massachusetts General Hospital Anorexia Nervosa February 2011 Phase 3
NCT02161614 Federal University of Minas Gerais|Fundação de Amparo à Pesquisa do estado de Minas Gerais Flow-mediated Dilation Evaluation of the Brachial Artery February 2014 Not Applicable
NCT01845649 Warner Chilcott Vulvovaginal Atrophy April 2013 Phase 3
NCT00066157 University of Wisconsin, Madison|National Institute on Aging (NIA) Alzheimer Disease September 2001 Phase 2|Phase 3
NCT00302731 Jeanne Drisko, MD, CNS, FACN|Private Foundation through KU Endowment|University of Kansas|University of Kansas Medical Center Menopause February 2006 Phase 2
NCT02238808 AHS Cancer Control Alberta Estrogen Receptor Positive Breast Cancer August 2015 Phase 2
NCT01165307 Abimbola Famuyide|Hologic, Inc.|Mayo Clinic Menorrhagia August 2009 Phase 4
NCT01553773 Federal University of São Paulo|Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Atrophy July 2004 Phase 2
NCT02744131 Kar Clinic & Hospital Pvt. Ltd.|All India Institute of Medical Sciences, New Delhi|Nova IVI Fertility, New Delhi|Dr Patil´s Fertility & Endoscopy Clinic, Bangalore|Shreyas Hospital & Sushrut Assisted Conception Clinic, Kolhapur|University of Messina Polycystic Ovary Syndrome May 2016 Not Applicable
NCT02114645 Zekai Tahir Burak Women´s Health Research and Education Hospital Infertility April 2014 Not Applicable
NCT01087879 University of Oulu Contraception October 2007 Not Applicable
NCT02255175 University of North Carolina, Chapel Hill|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institute of Mental Health (NIMH) Perimenopausal Depression October 1, 2015 Phase 4
NCT00191113 Eli Lilly and Company Turner Syndrome February 1989 Phase 3
NCT01780558 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Infertility January 2010 Not Applicable
NCT03789123 Bagcilar Training and Research Hospital|Kocaeli Derince Education and Research Hospital|Suleymaniye Birth And Women´s Health Education And Research Hospital Ovarian Reserve January 1, 2019 Phase 4
NCT01385280 University of Arizona|National Cancer Institute (NCI) Estrogen Receptor-positive Breast Cancer|Progesterone Receptor Positive Tumor|Recurrent Breast Cancer|Stage IIIC Breast Cancer|Stage IV Breast Cancer February 2011 Not Applicable
NCT03240081 Oregon Health and Science University Dyspareunia June 20, 2017 Phase 4
NCT01250210 Agile Therapeutics Ovulation Suppression September 2007 Phase 2
NCT00608062 University of Colorado, Denver|National Institute on Aging (NIA) Arterial Stiffening|Aging|Menopause March 2007 Not Applicable
NCT00455156 Health Decisions|Population Council|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Contraception December 2006 Phase 3
NCT03720847 University of North Carolina, Chapel Hill|National Institute of Mental Health (NIMH) Suicidal Ideation December 31, 2016 Phase 4
NCT02677259 One Fertility IVF May 2016 Phase 2
NCT03371654 University of Illinois at Chicago|National Institute of Mental Health (NIMH) Stress Disorders, Post-Traumatic|Healthy November 29, 2017 Phase 4
NCT01297348 Pfizer|Boston Collaborative Drug Surveillance Program Venous Thrombosis|Pulmonary Embolism|Sinus Thrombosis, Intracranial July 2007
NCT03043924 University Hospital, Lille|National Research Agency, France Polycystic Ovary Syndrome September 26, 2017 Not Applicable
NCT01432028 Denusa Wiltgen|Hospital de Clinicas de Porto Alegre|Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.|Conselho Nacional de Desenvolvimento Científico e Tecnológico|Federal University of Rio Grande do Sul Postmenopause March 2007 Not Applicable
NCT01943812 Peter Humaidan|Regionshospitalet Viborg, Skive Pregnancy Loss|Frozen Embryo Transfer December 2013 Phase 4
NCT02349386 BHR Pharma, LLC|H2O Clinical LLC|Q2 Solutions Cancer of the Prostate July 2015 Phase 2
NCT00160173 ASCEND Therapeutics|Solvay Pharmaceuticals Postmenopausal Symptoms Phase 4
NCT01040845 Mutual Pharmaceutical Company, Inc. Pharmacokinetics August 2007 Phase 1
NCT00465894 University of Alabama at Birmingham|Pfizer Overactive Bladder April 2007 Not Applicable
NCT01850095 Marco Alexandre Dias da Rocha|Fleury|Associacao Fundo de Incentivo a Psicofarmcologia|Bayer|Federal University of São Paulo Acne|Quality of Life March 2012 Not Applicable
NCT00206570 Bayside Health|National Alliance for Research on Schizophrenia and Depression|Stanley Medical Research Institute|National Health and Medical Research Council, Australia Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder January 2001 Phase 2
NCT00176644 University of Medicine and Dentistry of New Jersey|National Cancer Institute (NCI)|Rutgers, The State University of New Jersey Prostate Cancer May 2005 Phase 2
NCT00511355 Merck Sharp & Dohme Corp. Contraception October 2006 Phase 3
NCT01103518 Fundação Educacional Serra dos Órgãos Amenorrhea|Dysmenorrhea|Menstruation Disturbances|Hyperandrogenism December 2009 Phase 4
NCT02673606 Massachusetts General Hospital Healthy Naturally Cycling Women
NCT00905723 Federal University of São Paulo Postmenopausal Symptoms May 2009 Phase 3
NCT00195559 Wyeth is now a wholly owned subsidiary of Pfizer Premenstrual Syndrome|Menstruation Disturbances September 2005 Phase 3
NCT03620929 Fu Xing Hospital, Capital Medical University Asherman Syndrome August 13, 2018 Phase 4
NCT00789802 Washington University School of Medicine|American College of Obstetricians and Gynecologists Contraception|Bleeding November 2008 Not Applicable
NCT00653016 Janssen-Ortho Inc., Canada Female Contraception October 2002 Phase 4
NCT01923298 University of Arizona Estrogen Levels Among Breast Cancer Patients August 9, 2013 Phase 2
NCT02127593 Janssen Research & Development, LLC Healthy June 2013 Phase 1
NCT01218386 Universitair Ziekenhuis Brussel Infertility May 2010 Phase 4
NCT02872818 Kayseri Education and Research Hospital Apoptotic Signal Pathways in Endometrial Hyperplasia October 2014 Phase 4
NCT02496052 Beijing Obstetrics and Gynecology Hospital Intrauterine Adhesions January 2013 Not Applicable
NCT01668446 farzaneh hojjat|Razieh dehghani firouzabadi|Robab davar|Shahid Sadoughi University of Medical Sciences and Health Services Endometrial Preparation|Frozen Embryo Transfer September 2009 Phase 4
NCT01909141 Cairo University Polycystic Ovary Syndrome|Infertility August 2013 Early Phase 1
NCT01182207 Teva Pharmaceuticals USA Healthy July 2006 Phase 1
NCT00477633 Warner Chilcott Contraception June 2007 Phase 3
NCT03608241 Pfizer Healthy Females September 21, 2018 Phase 1
NCT01182194 Teva Pharmaceuticals USA Healthy June 2006 Phase 1
NCT03642665 Universitaire Ziekenhuizen Leuven|GZA Ziekenhuizen Campus Sint-Augustinus|Imelda Hospital, Bonheiden|Jessa Hospital Embryo Transfer September 1, 2018 Phase 4
NCT00455962 Massachusetts General Hospital|National Institutes of Health (NIH)|National Institute on Aging (NIA) Premenopause|Healthy January 2005 Phase 1|Phase 2
NCT00294463 Erasmus Medical Center|Organon Postmenopause|Osteoporosis February 2003 Phase 4
NCT02531321 University of Southern California Contraception|HIV August 2015 Phase 4
NCT00775086 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Female Contraception May 2004 Phase 1
NCT01613131 University of Colorado, Denver|Bayer Menopausal and Other Perimenopausal Disorders April 2012 Not Applicable
NCT02475265 Massachusetts General Hospital|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Anorexia Nervosa|Osteoporosis July 2015 Phase 2
NCT00837616 Nemours Children´s Clinic|Genentech, Inc. Turner Syndrome|Hypogonadism|Premature Ovarian Failure January 2009 Phase 4
NCT01709318 Merck Sharp & Dohme Corp. Contraception December 2012 Phase 2
NCT02406690 Reproductive Medicine Associates of New Jersey Endometrial Dysfunction July 31, 2015
NCT00754065 Bayer Contraception September 2008 Phase 3
NCT03724955 Emory University Cystic Fibrosis Related Bone Disease December 2018 Phase 4
NCT00005108 National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) Atherosclerosis|Healthy|Vascular Disease April 2000 Phase 2
NCT00251082 Solvay Pharmaceuticals Postmenopause December 2005 Phase 3
NCT03120728 University of Southern California Emergency Contraception|Healthy, Reproductive Age Women July 10, 2017 Phase 4
NCT02668796 Glenmark Pharmaceuticals Ltd. India Vulvar and Vaginal Atrophy January 2016 Phase 3
NCT03351205 Beijing Obstetrics and Gynecology Hospital Intrauterine Adhesion November 21, 2017 Not Applicable
NCT01501448 IVI Madrid Infertility January 2012 Phase 4
NCT00816556 Maire Mac Bride|National Center for Advancing Translational Science (NCATS)|Mayo Clinic Atrophic Vaginitis October 2008 Phase 3
NCT01698164 Peking Union Medical College Hospital Menopausal Syndrome|Cardiovascular Disease|Osteoporosis|Breast Cancer December 2008 Phase 4
NCT02218463 Children´s Mercy Hospital Kansas City|University of Missouri, Kansas City Prepubertal Labial Adhesions September 2014 Not Applicable
NCT03531437 Mahidol University Contraception|Hypercoagulability March 2016 Phase 4
NCT03749733 Grünenthal GmbH|Grünenthal Colombiana S.A. Bioequivalence February 2019 Phase 1
NCT01942668 TherapeuticsMD Menopause August 5, 2013 Phase 3
NCT01511822 AGUNCO Obstetrics and Gynecology Centre PCOS|Polycystic Ovary Syndrome Phase 4
NCT03662516 Pfizer Healthy Females September 26, 2018 Phase 1
NCT01659008 Kay I Waud MD PhD|American College of Obstetricians and Gynecologists|Eastern Virginia Medical School Menstrual Cycle and Uterine Bleeding Disorders June 2012 Not Applicable
NCT02872818 Kayseri Education and Research Hospital Apoptotic Signal Pathways in Endometrial Hyperplasia October 2014 Phase 4
NCT03346317 Beijing Obstetrics and Gynecology Hospital Intrauterine Adhesion November 16, 2017 Not Applicable
NCT00044837 National Institute of Allergy and Infectious Diseases (NIAID) HIV Infections Phase 1
NCT02846142 Proteostasis Therapeutics, Inc. Healthy Volunteer June 2016 Phase 1
NCT00662454 Oregon Health and Science University|National Institutes of Health (NIH)|Oregon Clinical and Translational Research Institute Contraception|Body Weight January 2006 Phase 4
NCT01705249 Novo Nordisk A+S Menopause|Healthy August 14, 2001 Phase 4
NCT01310647 Instituto de Investigacion Sanitaria La Fe Ovarian Diseases June 2011 Phase 2
NCT01780610 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Infertility January 2012 Not Applicable
NCT00080756 City of Hope Medical Center|National Cancer Institute (NCI) brca1 Mutation Carrier|brca2 Mutation Carrier|Breast Cancer March 11, 2004 Phase 2
NCT02847806 University Hospital, Caen Hypogonadism January 2008 Phase 3
NCT02186782 Maher elesawi kamel elesawi|Mansoura University Infertility|Anovulation June 2014 Phase 4
NCT00154180 Kronos Longevity Research Institute|Albert Einstein College of Medicine, Inc.|Brigham and Women´s Hospital|Columbia University|Mayo Clinic|University of California, San Francisco|University of Utah|University of Washington|Yale University Menopause|Arteriosclerosis September 2005 Phase 4
NCT00732693 University of Edinburgh Premature Ovarian Failure February 2002 Phase 4
NCT00740194 University Hospital, Ghent Healthy August 2008 Phase 1|Phase 2
NCT00236769 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Contraception|Female Contraception November 1997 Phase 3
NCT00722761 Massachusetts General Hospital|Bayer Acne Vulgaris April 2009 Phase 3
NCT00161681 Wyeth is now a wholly owned subsidiary of Pfizer Premenstrual Syndrome July 2005 Phase 3
NCT00030147 National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) Perimenopausal Depression|Depression February 2002 Phase 4
NCT03336437 Oregon Health and Science University Menopause February 1, 2018 Phase 4
NCT00293059 Bayer Metrorrhagia December 2005 Phase 3
NCT00744328 Northwestern University Postpartum Depression August 2008 Phase 4
NCT03294538 Actavis Inc. Atrophic Vaginitis May 18, 2016 Phase 3
NCT02449902 TherapeuticsMD Menopause|Vulvovaginal Atrophy|Painful Intercourse|Dyspareunia July 2013 Phase 2
NCT01388491 Teva Branded Pharmaceutical Products, R&D Inc.|Teva Pharmaceutical Industries Hemostasis|Oral Contraceptive October 2011 Phase 2
NCT01605071 University of Colorado, Denver|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Insulin Resistance September 2011 Not Applicable
NCT02859285 ProHealth Care, Inc Hypoactive Sexual Desire Disorder April 2016 Not Applicable
NCT01986764 University of Pennsylvania Planned RRSO July 1, 2013 Not Applicable
NCT03249402 Janssen-Cilag International NV Healthy August 14, 2017 Phase 1
NCT01046643 University of Michigan|National Institute on Aging (NIA) Menopausal Syndrome May 2010 Not Applicable
NCT01779947 Amneal Pharmaceuticals, LLC Atrophic Vaginitis Due to Menopause March 2012 Phase 3
NCT00324259 Washington University School of Medicine Breast Neoplasms August 2004 Phase 2
NCT03124524 Adana Numune Training and Research Hospital Primary Dysmenorrhea January 15, 2015 Phase 4
NCT03060304 Sun Yat-sen University Endometrium March 2017 Phase 4
NCT03155048 Memorial Sisli Hospital, Istanbul Infertility May 1, 2017 Not Applicable
NCT00117273 Duramed Research|Teva Pharmaceutical Industries Healthy June 2005 Phase 3
NCT02021097 Regenex Pharmaceutical, China Oral Contraceptive February 2012 Phase 3
NCT01419353 Meir Medical Center Infertility August 2011 Phase 4
NCT00026962 National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) Breast Cancer September 1999 Phase 2
NCT02103569 Bristol-Myers Squibb Hepatitis C April 2014 Phase 1
NCT01723579 Merck Sharp & Dohme Corp. Contraception July 2013 Phase 3
NCT00391417 BioSante Pharmaceuticals Hot Flashes September 2003 Phase 3
NCT03518528 University Hospital, Angers Embryo Transfer|Infertility August 30, 2018
NCT00447863 Wyeth is now a wholly owned subsidiary of Pfizer Contraception August 2007 Phase 1
NCT00435175 University of Aarhus Postmenopause June 2005 Not Applicable
NCT02253173 TherapeuticsMD Vulvovaginal Atrophy|Menopause|Dyspareunia|Painful Intercourse September 2014 Phase 3
NCT03779633 Medical University of Vienna Pelvic Organ Prolapse February 2, 2017 Phase 4
NCT00127075 Hospices Civils de Lyon Multiple Sclerosis June 2005 Phase 3
NCT00612508 Oregon Health and Science University|Oregon Clinical and Translational Research Institute Contraceptive Usage|Vaginal Epithelial Disruption May 2007 Not Applicable
NCT00059228 National Institute of Mental Health (NIMH)|National Institutes of Health Clinical Center (CC) Postpartum Depression|Depression April 17, 2003 Phase 2
NCT03069781 McMaster University Muscle Atrophy May 2017 Early Phase 1
NCT00547001 Hartford Hospital Hot Flashes|Night Sweats August 2007 Not Applicable
NCT01126801 Massachusetts General Hospital|National Institutes of Health (NIH) Menopausal Depression May 2010 Phase 2
NCT01546454 Oregon Health and Science University|Medical Research Foundation, Oregon Coronary Heart Disease February 2012 Not Applicable
NCT01268046 Massachusetts General Hospital|National Institute on Aging (NIA) Memory Loss|Cognitive Changes|Postmenopausal Symptoms November 2009 Phase 1|Phase 2
NCT01153581 Yale University|National Heart, Lung, and Blood Institute (NHLBI) Orthostatic Intolerance February 2006 Phase 2
NCT00755963 Medical University of Vienna Hormone Replacement May 2009 Phase 4
NCT00357006 The Alfred|Stanley Medical Research Institute Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder(Not in Manic Phase) July 2006 Phase 2
NCT02668783 Merck Sharp & Dohme Corp. Moderate to Severe Primary Dysmenorrhea February 11, 2016 Phase 3
NCT00303784 Imperial College London|Medical Research Council|University College, London Anemia|Cardiovascular Complications|Hot Flashes|Osteoporosis|Prostate Cancer March 2006 Phase 3
NCT00472004 Wyeth is now a wholly owned subsidiary of Pfizer Vasomotor Symptoms February 2006 Phase 4
NCT02245438 Boehringer Ingelheim Healthy May 2002 Phase 1
NCT03788681 Ain Shams University ICSI April 1, 2018 Phase 3
NCT00649896 Mylan Pharmaceuticals Healthy August 2003 Phase 1
NCT00000559 National Heart, Lung, and Blood Institute (NHLBI) Cardiovascular Diseases|Coronary Disease|Heart Diseases|Myocardial Ischemia|Postmenopause March 1995 Phase 3
NCT00042289 National Institute of Allergy and Infectious Diseases (NIAID)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) HIV Infections March 2003 Phase 4
NCT01087593 Ostergotland County Council, Sweden Fibromyalgia August 2001 Not Applicable
NCT01389102 Lumara Health, Inc. Hot Flashes December 2004 Phase 3
NCT01344369 Teva Pharmaceuticals USA Healthy August 2008 Phase 1
NCT01056042 Prince of Songkla University Endometriosis June 2007 Phase 4
NCT01200537 Duke University|Emory University IVF Poor Responders October 2010 Not Applicable
NCT01353846 Instituto Valenciano de Infertilidad, IVI VALENCIA Infertility May 2011 Phase 4
NCT03236545 University of Delaware|American Heart Association Cardiovascular Risk Factor July 1, 2016 Not Applicable
NCT01790282 Mansoura Integrated Fertility Center IVF|Infertility March 2013 Not Applicable
NCT02224313 Intira Sriprasert|TherapeuticsMD|Eastern Virginia Medical School Menopause December 2015 Not Applicable
NCT00446199 Bayer Vasomotor Symptoms|Hot Flashes March 2007 Phase 3
NCT03074045 Bayer Contraception March 13, 2017 Phase 3
NCT01633814 University of Missouri-Columbia Menopause|Aging|Blood Pressure September 2011 Not Applicable
NCT02273791 Mansoura University Infertility|Polycystic Ovarian Syndrome December 2013
NCT00195455 Wyeth is now a wholly owned subsidiary of Pfizer Postmenopause February 2005 Phase 4
NCT01822288 Far Eastern Memorial Hospital Menopausal Syndromes December 2012 Phase 4
NCT01810315 CONRAD HIV Prevention September 2013 Phase 1
NCT01753102 Sun Pharmaceutical Industries Limited Vulvar Atrophy|Vaginal Atrophy November 6, 2012 Phase 3
NCT00320567 McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc. Osteoporosis Phase 2
NCT03324685 Biogen Drug Interactions November 11, 2017 Phase 1
NCT00254800 AstraZeneca|Eli Lilly and Company Type 2 Diabetes Mellitus November 2005 Phase 1
NCT02485821 Ain Shams University Failed Induction of Labor June 2015 Phase 2|Phase 3
NCT00633360 Massachusetts General Hospital|Bayer Premenstrual Syndrome|Depression February 2008 Not Applicable
NCT03740204 Massachusetts General Hospital Eating Disorders|Hypoestrogenemia April 1, 2019 Phase 2
NCT03301233 Ain Shams University Endometrial Thickness November 1, 2017 Not Applicable
NCT00033358 National Cancer Institute (NCI) Endometrial Cancer February 2002 Phase 2
NCT01293747 Productos Científicos S. A. de C. V. Menopause February 2011 Phase 1
NCT00829114 FHI 360|United States Agency for International Development (USAID)|Makerere University|RHRU National Office, University of Witwatersand, Johannesburg HIV+AIDS|HIV Infections March 2009 Phase 4
NCT00459810 OHSU Knight Cancer Institute|National Cancer Institute (NCI) Prostate Cancer February 2007 Phase 2
NCT00687739 University of Colorado, Denver|National Institute on Aging (NIA) Obesity May 2008 Phase 3
NCT00319163 Wyeth is now a wholly owned subsidiary of Pfizer Healthy May 2006 Phase 1
NCT03300518 Reproductive & Genetic Hospital of CITIC-Xiangya|Merck Sharp & Dohme Corp. Infertility November 15, 2017 Not Applicable
NCT02792153 Johns Hopkins University Anorexia Nervosa December 2016 Phase 1
NCT00332553 Eli Lilly and Company Vasomotor Symptoms|Endometrial Safety February 2002 Phase 2
NCT00685906 AstraZeneca Healthy April 2008 Phase 1
NCT00344383 McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc. Metrorrhagia November 2003 Phase 2
NCT00261482 Janssen Pharmaceutica N.V., Belgium Contraception|Female Contraception July 2003 Phase 4
NCT00307801 Bayer Metrorrhagia February 2006 Phase 3
NCT03385551 Instituto Palacios Vulvovaginal Atrophy December 2, 2018
NCT00212277 Nobelpharma Dysmenorrhea February 2005 Phase 3
NCT00860964 Peking Union Medical College Osteoporosis February 1998 Phase 4
NCT03479879 Ain Shams University Miscarriage March 21, 2018 Phase 2|Phase 3
NCT03033160 Boston Urogynecology Associates|Beth Israel Deaconess Medical Center|Mount Auburn Hospital Asymptomatic Microscopic Hematuria December 2016 Phase 4
NCT03493126 Pamela Smith|Ohio State University Vaginal Atrophy October 15, 2018 Phase 4
NCT00134745 Line Cleemann|Novo Nordisk A+S|The County of Frederiksborg|The foundation of Kaptajnløjtnant Harald Jensen and Wife|The foundation of Mrs. Olga Bryde|The foundation of Mr. Ivan Nielsen|Hillerod Hospital, Denmark Turner Syndrome June 2005 Phase 4
NCT01070979 Warner Chilcott Hormone Replacement Therapy February 2003 Phase 3
NCT01120665 University of Sao Paulo General Hospital|Fundação de Amparo à Pesquisa do Estado de São Paulo Women´s Health February 2002 Not Applicable
NCT02533427 Gilead Sciences HCV Infection October 2015 Phase 1
NCT00650442 Mylan Pharmaceuticals Healthy January 2003 Phase 1
NCT01455597 Warner Chilcott Vulvovaginal Atrophy October 2011 Phase 3
NCT00426972 Renovo Burn|Trauma|Varicose Ulcer January 2007 Phase 3
NCT00357604 Bristol-Myers Squibb HIV Infections July 2006 Phase 1
NCT01221831 Estetra Contraception September 2010 Phase 2
NCT00006133 National Center for Research Resources (NCRR)|University of Alabama at Birmingham Systemic Lupus Erythematosus June 2000 Not Applicable
NCT01065220 Medical University of Vienna Transsexualism February 2010 Phase 4
NCT00248963 Wyeth is now a wholly owned subsidiary of Pfizer Oral Contraceptive Phase 3
NCT02715232 Medical University of Vienna Gender Dysphoria February 6, 2017 Phase 4
NCT00471991 Bayer Oral Contraceptive April 2007 Phase 2
NCT01291004 Teva Branded Pharmaceutical Products, R&D Inc.|Teva Pharmaceutical Industries Follicle Development|Ovarian Follicle|Follicle Count|Follicle Size|Oral Contraceptive January 2011 Phase 1
NCT02455453 Washington University School of Medicine Breast Cancer April 28, 2015 Phase 2
NCT03003949 University of North Carolina, Chapel Hill|National Institute of Mental Health (NIMH) Perimenopausal Disorder|Stress, Emotional January 24, 2017 Phase 1|Phase 2
NCT01710696 Novo Nordisk A+S Genetic Disorder|Turner Syndrome July 23, 1998 Phase 3
NCT00245921 Wyeth is now a wholly owned subsidiary of Pfizer Contraception February 2003 Phase 3
NCT03238092 Hospital de Clinicas de Porto Alegre Fertility Disorders August 2017 Phase 3
NCT02866786 S.C.B. Medical College and Hospital Polycystic Ovary Syndrome August 15, 2016 Phase 4
NCT00455741 Massachusetts General Hospital|National Institute on Aging (NIA) Postmenopause|Aging November 2000 Phase 1|Phase 2
NCT03755037 Nesreen Abdel Fattah Abdullah Shehata|Beni-Suef University Female Infertility January 31, 2017 Phase 1
NCT01340625 Teva Pharmaceuticals USA Bioequivalence December 2006 Phase 1
NCT01367912 Zekai Tahir Burak Women´s Health Research and Education Hospital Infertility February 2008 Not Applicable
NCT01817530 AbbVie Heavy Uterine Bleeding|Uterine Fibroids April 8, 2013 Phase 2
NCT01762943 University of North Carolina, Chapel Hill|Foundation of Hope, North Carolina|North Carolina Translational and Clinical Sciences Institute|National Institutes of Health (NIH)|National Alliance for Research on Schizophrenia and Depression|National Institute of Mental Health (NIMH) Postpartum Depression August 2013 Not Applicable
NCT00320580 McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc. Metrorrhagia Phase 2
NCT02486757 Massachusetts General Hospital Menstruation Disturbances April 2015 Early Phase 1
NCT02352090 Helsinki University Central Hospital|Oulu University Hospital Contraception February 2015 Phase 4
NCT02467673 University Potiguar|InBios International, Inc.|Federal University of São Paulo Menopausal Syndrome January 2012 Phase 2
NCT03172533 University of Erlangen-Nürnberg Medical School Anorexia Nervosa March 15, 2016 Phase 2
NCT00711607 Merck Sharp & Dohme Corp.|CRS Mannheim GmbH Healthy May 2007 Phase 1
NCT01500863 IVI Madrid Ovarian Hyperstimulation Syndrome November 2011 Phase 4
NCT02122198 University of Colorado, Denver Cognitive Impairment|Executive Dysfunction|Endothelial Dysfunction|Cardiovascular Disease September 8, 2014 Not Applicable
NCT02316249 Northwell Health Atrophy of Vagina|Vaginal Ulceration|Vaginitis April 2015 Phase 2
NCT02757469 Navy General Hospital, Beijing Primary Ovarian Insufficiency|Menopause, Premature May 2016 Not Applicable
NCT01308814 University of North Carolina, Chapel Hill|National Institute of Mental Health (NIMH) Perimenopause|Menopause|Depression October 2010 Phase 2|Phase 3
NCT00254865 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Contraception|Female Contraception August 2002 Phase 1
NCT00003771 Regional Oncologic Center|Scandinavian Breast Group|International Breast Cancer Study Group|European Organisation for Research and Treatment of Cancer - EORTC|National Cancer Institute (NCI) Breast Cancer|Menopausal Symptoms September 1997 Phase 3
NCT00997893 University of Illinois at Chicago|National Institute of Mental Health (NIMH) Menopause|Hot Flashes December 2009 Phase 2
NCT01958073 University of California, San Diego|American Urogynecologic Society|New York University School of Medicine Recurrent Urinary Tract Infection October 2013 Phase 4
NCT02984696 Catholic University of the Sacred Heart Hypothalamic Amenorrhea March 2015 Not Applicable
NCT02251925 Royan Institute Infertility September 2012 Phase 3
NCT00442689 Northwestern University|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Polycystic Ovary Syndrome|Metabolic Syndrome July 2006 Not Applicable
NCT01381016 University of Colorado, Denver Obesity|Infertility June 2011 Not Applicable
NCT01596010 Novo Nordisk A+S Menopause|Healthy October 2007 Phase 1
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NCT02577601 Oregon Health and Science University|Society of Family Planning Contraception September 8, 2015 Phase 4
NCT00391807 Warner Chilcott Contraception November 2006 Phase 3
NCT01477632 Novo Nordisk A+S Menopause|Healthy March 2005 Phase 1
NCT00160316 Solvay Pharmaceuticals Postmenopause April 2005 Phase 3
NCT00254189 Wyeth is now a wholly owned subsidiary of Pfizer Ovulation December 2002 Phase 2
NCT03401047 University of Virginia Polycystic Ovary Syndrome November 30, 2017 Early Phase 1
NCT03359057 Galeno Desenvolvimento de Pesquisas Clínicas|Biolab Sanus Farmaceutica Contraception February 26, 2013 Phase 3
NCT03395665 Institut Universitari Dexeus Infertility|Preimplantation Genetic Diagnosis+Screening|Miscarriage January 2014
NCT01251263 Scott and White Hospital & Clinic Menstrual Migraines|Menstrual Bleeding|Menstrual Spotting October 2010 Phase 4
NCT00128934 Wyeth is now a wholly owned subsidiary of Pfizer Menstruation Disturbances|Premenstrual Syndrome August 2005 Phase 3
NCT03547024 Janssen-Cilag International NV Healthy June 8, 2018 Phase 1
NCT00113100 University of Michigan Skin Wrinkling August 2004 Not Applicable
NCT00108238 US Department of Veterans Affairs|VA Office of Research and Development Healthy April 2003 Phase 4
NCT00946192 Massachusetts General Hospital|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Exercise-related Amenorrhea May 2009 Phase 3
NCT01052623 Johann Wolfgang Goethe University Hospital Ataxia Telangiectasia|Growth Failure January 2010 Phase 4
NCT03651427 Hospital de Clinicas de Porto Alegre Gender Dysphoria February 13, 2017 Not Applicable
NCT01980680 Peter Humaidan|Regionshospitalet Viborg, Skive Infertility December 2014 Phase 4
NCT00490308 Assaf-Harofeh Medical Center Infertility August 2007 Phase 1
NCT01031355 Bayer Contraception|Ovulation Inhibition December 2009 Phase 1
NCT01441635 AbbVie (prior sponsor, Abbott)|AbbVie Heavy Uterine Bleeding|Uterine Fibroids September 2011 Phase 2
NCT02736032 Cairo University|Nile Ivf Center, Cairo, Egypt|Kamal Shaeer center of infertility Infertility March 2016 Phase 3
NCT02524561 Brigham and Women´s Hospital|National Cancer Institute (NCI)|Kronos Longevity Research Institute|Albert Einstein College of Medicine, Inc.|Columbia University|Mayo Clinic|University of California, San Francisco|University of Utah|University of Washington|Yale University Mammographic Density|Abnormal Mammogram September 2005 Not Applicable
NCT02352597 Cairo University Polycystic Ovaries January 2013 Phase 4
NCT03498313 University of Illinois at Chicago|National Institute of Mental Health (NIMH) Suicidal Ideation April 15, 2018 Phase 4
NCT00326404 The Hospital for Sick Children|The Physicians´ Services Incorporated Foundation Contraception May 2006 Phase 3
NCT00140998 Nemours Children´s Clinic|Eli Lilly and Company Turner Syndrome|Hypogonadism|Premature Ovarian Failure January 2001 Phase 3
NCT01973816 University Hospital, Rouen Endometriosis November 2014 Phase 3
NCT00213096 Population Council|United States Agency for International Development (USAID) Contraception March 2003 Phase 2
NCT01015677 Merck Sharp & Dohme Corp. Moderate to Severe Vasomotor Symptoms in Postmenopausal|Women December 17, 2009 Phase 2
NCT00258063 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Contraception|Female Contraception May 2004 Phase 1
NCT00775242 Centro A.F. de Estudios Tecnologicos, S.A. Menopause April 2007 Phase 2|Phase 3
NCT02195986 Mylan Inc.|Mylan Pharmaceuticals Atrophic Vaginitis June 2014 Phase 3
NCT00167648 University of Washington|Pacific Northwest SPORE (Specialized Projects in Oncology Research Excellence) Cancer|Prostate Neoplasms March 2005 Phase 2
NCT02995694 Alvogen Pine Brook LLC Atrophic Vaginitis April 2016 Phase 3
NCT00237042 University of Washington|National Institute of Dental and Craniofacial Research (NIDCR) Temporomandibular Joint Disorders October 2005 Not Applicable
NCT02670785 Warner Chilcott Vulvovaginal Atrophy|Menopause|Dyspareunia February 15, 2016 Phase 2
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (550.70 mM; Need ultrasonic)

Ethanol : 20 mg/mL (73.43 mM; Need ultrasonic)

Preparing
Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 3.6713 mL 18.3567 mL 36.7134 mL
5 mM 0.7343 mL 3.6713 mL 7.3427 mL
10 mM 0.3671 mL 1.8357 mL 3.6713 mL
*Please refer to the solubility information to select the appropriate solvent.

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