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Hydrocortisone

Hydrocortisone

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商品描述
Hydrocortisone,HY-N0583,MCE：
Description

Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer. Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT00005802 Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) Leukemia June 1999 Phase 1|Phase 2
NCT02700828 Semmelweis University Hypoxic-Ischemic Encephalopathy|Asphyxia February 2016 Phase 2|Phase 3
NCT00682487 Meir Medical Center Acute Myocardial Infarction June 2008
NCT02768740 Association Niçoise de Réanimation Médicale Septic Shock April 2008 Phase 4
NCT00392834 AIDS Malignancy Consortium|National Cancer Institute (NCI)|The EMMES Corporation Lymphoma September 2006 Phase 2
NCT00460031 Case Comprehensive Cancer Center|National Cancer Institute (NCI) Prostate Cancer September 1, 2006 Phase 2
NCT03602378 University of Split, School of Medicine|General Hospital Zadar Developmental Disability|Chronic Disease|Down Syndrome|Autism Spectrum Disorder|Pervasive Developmental Disorder|Cerebral Palsy|Diabetes Mellitus, Type 1|Epilepsy|Asthma|Stress April 2, 2018
NCT01608945 Eastern Hepatobiliary Surgery Hospital Some Studies Shows That the Steroid Can Reduce the Injury of the I+R of the Liver April 2008
NCT01817153 Centre Hospitalier Régional d´Orléans Septic Shock|Adult November 2013 Phase 2|Phase 3
NCT00590018 Baylor College of Medicine Cardiac Output, Low February 2003 Phase 2
NCT00542841 Maria I. New|Office of Rare Diseases (ORD)|National Center for Research Resources (NCRR)|Icahn School of Medicine at Mount Sinai 21-hydroxylase Deficiency August 2007 Not Applicable
NCT00136435 Dana-Farber Cancer Institute|Brigham and Women´s Hospital|Massachusetts General Hospital|Queen Elizabeth II Health Sciences Centre Acute Lymphoblastic Leukemia June 2002 Phase 2
NCT00720109 National Cancer Institute (NCI) Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1|Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia July 2008 Phase 2|Phase 3
NCT03773822 CMC Ambroise Paré Cardiogenic Shock December 21, 2018 Phase 3
NCT01090518 Bronx VA Medical Center|Lightfighter Trust PTSD February 2010 Not Applicable
NCT00147004 Hadassah Medical Organization|European Society of Intensive Care Medicine|International Sepsis Forum|The Gorham Foundation Shock, Septic March 2002 Phase 3
NCT02756546 Cairo University Systemic Lupus Erythematosis September 2014 Phase 1|Phase 2
NCT01448109 The George Institute|National Health and Medical Research Council, Australia|Australian and New Zealand Intensive Care Society Clinical Trials Group Septic Shock June 13, 2012 Phase 4
NCT00805285 University of Maryland Inflammatory Bowel Disease|Ulcerative Colitis October 2008 Phase 2
NCT03015246 Wayne State University Heroin Dependence|Opioid Use Disorder December 2016 Phase 1
NCT00084838 Dana-Farber Cancer Institute|National Cancer Institute (NCI) Central Nervous System Tumor, Pediatric February 2003 Phase 2
NCT00002865 Wake Forest University Health Sciences|National Cancer Institute (NCI) Leukemia April 1995 Phase 2
NCT01867294 Academic and Community Cancer Research United|National Cancer Institute (NCI) Advanced Malignant Neoplasm|Dermatologic Complication August 31, 2012 Phase 2
NCT00451230 National Institute on Drug Abuse (NIDA)|National Alliance for Research on Schizophrenia and Depression Cocaine Dependence June 2005 Not Applicable
NCT02517489 University Hospital, Tours Community Acquired Pneumonia October 2015 Phase 3
NCT00309894 University of California, San Francisco|National Cancer Institute (NCI) Prostate Cancer April 2004 Phase 2
NCT00002494 Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) Leukemia|Lymphoma May 1992 Phase 2
NCT00006455 Gustave Roussy, Cancer Campus, Grand Paris|National Cancer Institute (NCI) Lymphoma December 1999 Phase 3
NCT02775227 Helsinki University Central Hospital Pancreatic Fistula|Pancreatic Neoplasms May 2016 Phase 4
NCT01874860 University of Louisville|James Graham Brown Cancer Center Colorectal Cancer|Head and Neck Cancer August 2013 Phase 2
NCT00270777 University of Kelaniya Snake Bites March 2005 Phase 4
NCT02671058 Cristcot LLC|Parexel Healthy March 2016 Phase 1
NCT01860664 Koffler Vision Group|Fera Pharmaceuticals, LLC Allergic Conjunctivitis May 2013 Phase 2
NCT01047670 Unidade de Terapia Intensiva Mechanical Ventilation|Mortality May 2008 Phase 2|Phase 3
NCT02101853 National Cancer Institute (NCI) B Acute Lymphoblastic Leukemia December 8, 2014 Phase 3
NCT03670212 Wayne State University|National Institute on Drug Abuse (NIDA) Cigarette Smoking January 7, 2016 Phase 1
NCT00001521 Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) Congenital Adrenal Hyperplasia (CAH) February 2, 1996 Phase 2
NCT03209102 Institut National de la Santé Et de la Recherche Médicale, France Borderline Personality Disorder|Adolescent Development July 2017 Phase 2
NCT00002744 Children´s Oncology Group|National Cancer Institute (NCI) Leukemia May 1996 Phase 3
NCT02043587 University of California, San Diego|Leadiant Biosciences, Inc. Acute Lymphocytic Leukemia|Adult Lymphoblastic Lymphoma January 2014 Phase 2
NCT01954056 NICHD Neonatal Research Network|National Center for Research Resources (NCRR)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Infant, Newborn, Diseases|Cardiovascular Insufficiency July 2014 Phase 3
NCT00705822 Sanofi Prostatic Neoplasms August 2006 Phase 3
NCT00591006 University of Texas Southwestern Medical Center Healthy January 2008 Phase 3
NCT01005758 Ohio State University Comprehensive Cancer Center|National Cancer Institute (NCI) Leukemia January 2009 Phase 2
NCT02419755 St. Jude Children´s Research Hospital Mixed Lineage Acute Leukemia|Acute Myeloid Leukemia|Acute Lymphoid Leukemia April 14, 2015 Phase 2
NCT00895310 University of California, Davis Prostate Cancer May 2009 Phase 2
NCT00623740 Assistance Publique - Hôpitaux de Paris Bronchopulmonary Dysplasia April 2008 Phase 3
NCT02889224 University Hospital, Bordeaux Cushing´s Syndrome February 2012 Not Applicable
NCT03153917 Hospices Civils de Lyon Shift-Work Sleep Disorder June 2, 2017 Not Applicable
NCT00980876 Farmoquimica S.A.|Pharmagenix Projetos em Medicina Farmacêutica Ltda. Otitis Externa April 2012 Phase 3
NCT00003728 European Organisation for Research and Treatment of Cancer - EORTC|National Cancer Institute (NCI) Leukemia|Lymphoma December 1998 Phase 3
NCT01540812 PETHEMA Foundation Acute Lymphoblastic Leukemia February 2012
NCT00002921 Southwest Oncology Group|National Cancer Institute (NCI) Adrenocortical Carcinoma March 1997 Phase 2
NCT00859781 Weill Medical College of Cornell University Prostate Cancer June 2009 Phase 2
NCT00358748 University of British Columbia|BC Research Inc. Neonatal Hypotension July 2005 Phase 3
NCT01301677 X-pert Med GmbH Erythema|Pain January 2011 Phase 1
NCT00899847 Stanford University Transplantation, Homologous|Transplantation, Autologous|Multiple Myeloma|Blood and Marrow Transplant (BMT) May 2009 Phase 2
NCT00874393 NICHD Neonatal Research Network|National Center for Research Resources (NCRR)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Infant, Newborn|Infant, Low Birth Weight|Infant, Small for Gestational Age|Infant, Premature|Hypotension|Blood Pressure July 2009 Phase 1
NCT00476190 Dana-Farber Cancer Institute|Massachusetts General Hospital|Boston Children´s Hospital|NCIC Clinical Trials Group Acute Lymphoblastic Leukemia April 2007 Phase 2
NCT02722200 Yale University Obesity May 2016 Phase 1
NCT02282150 Ulla Feldt-Rasmussen|Rigshospitalet, Denmark Adrenal Insufficiency October 2016 Phase 4
NCT01453686 The Hospital for Sick Children Alopecia Areata August 2002 Phase 3
NCT02465307 University of Florida|National Science Foundation Delirium|Confusion February 2016
NCT03688789 Rennes University Hospital Haematological Malignancy January 1, 2019 Not Applicable
NCT00704262 LEO Pharma Psoriasis Vulgaris May 2008 Phase 2
NCT03509350 Emory University|The Marcus Foundation Sepsis August 22, 2018 Phase 3
NCT03585829 University Tunis El Manar Corticotropin Deficiency|Fasting May 17, 2018 Phase 4
NCT00002757 Children´s Oncology Group|National Cancer Institute (NCI)|Societe Francaise Oncologie Pediatrique|Children´s Cancer and Leukaemia Group Leukemia|Lymphoma June 2001 Phase 3
NCT01095172 Guy´s and St Thomas´ NHS Foundation Trust|Astellas Pharma Europe Ltd. Function of Renal Transplant November 2010 Phase 4
NCT01104025 Children´s Hospital Medical Center, Cincinnati Hemophagocytic Lymphohistiocytosis April 2010 Phase 2
NCT00490828 Ludwig-Maximilians - University of Munich Systemic Inflammatory Response Syndrome|Posttraumatic Stress Disorder June 2007 Phase 4
NCT03165344 Peking University Third Hospital Esophageal Stenosis Acquired February 10, 2017 Not Applicable
NCT03110198 Xijing Hospital of Digestive Diseases|Shanghai Tongji Hospital, Tongji University School of Medicine|First Affiliated Hospital of Zhongshan Medical University Ulcerative Colitis, Unspecified May 2017 Phase 4
NCT00673270 Rennes University Hospital Renin Angiotensin May 2008 Phase 1|Phase 2
NCT00362661 University of Zurich Posttraumatic Stress Disorder June 2007 Not Applicable
NCT02349217 M.D. Anderson Cancer Center Breast Cancer January 2015 Not Applicable
NCT00002704 National Cancer Institute (NCI) Leukemia January 1996 Phase 2
NCT00709839 Medical University of Vienna Healthy June 2008 Phase 4
NCT00862381 University Hospital, Grenoble Patient Admitted in Reanimation October 2008 Phase 3
NCT00002785 Children´s Oncology Group|National Cancer Institute (NCI) Leukemia July 1996 Phase 2
NCT00003593 Children´s Oncology Group|National Cancer Institute (NCI) Leukemia|Myelodysplastic Syndromes|Myelodysplastic+Myeloproliferative Neoplasms June 1999 Phase 3
NCT03019614 Diurnal Limited|Simbec Research Congenital Adrenal Hyperplasia|Adrenal Insufficiency March 2010 Phase 1
NCT02689856 Citius Pharmaceuticals, Inc. Hemorrhoids May 2015 Phase 2
NCT03718234 University of Minnesota - Clinical and Translational Science Institute|FDA Office of Orphan Products Development Congenital Adrenal Hyperplasia|Hyperplasia|Adrenal Hyperplasia|Congenital Disorders|Adrenocortical Hyperfunction|Disorders of Sex Development|Urogenital Abnormalities|Genetic Diseases, Inborn|Steroid Metabolic Diseases, Inborn|Adrenal Gland Disease|Hydrocortisone January 1, 2019 Phase 1|Phase 2
NCT01960530 Diurnal Limited|Simbec Research Adrenal Insufficiency October 2013 Phase 1
NCT02602210 Universitaire Ziekenhuizen Leuven Liver Cirrhosis January 2015 Phase 3
NCT00167544 Nationwide Children´s Hospital|National Institutes of Health (NIH)|National Institute of Neurological Disorders and Stroke (NINDS) Bronchopulmonary Dysplasia|Encephalomalacia|Premature Birth November 2005 Phase 2
NCT03623555 Ximena Goldberg|Fundación Bancaria La Caixa|Universitat Autonoma de Barcelona|Associació Catalana d´Universitats Públiques|Corporacion Parc Tauli Violence, Domestic|Stress Related Disorder|Depressive Disorder September 2018
NCT00732277 University Hospital Southampton NHS Foundation Trust|Imperial College London|St Mary´s NHS Trust|University of Bristol|University Hospitals Bristol NHS Foundation Trust Sepsis April 2008 Phase 2
NCT00640822 LEO Pharma Psoriasis Vulgaris February 2008 Phase 3
NCT03302416 University of Pittsburgh|National Institute on Drug Abuse (NIDA) Healthy June 1, 2016 Early Phase 1
NCT00751855 VISN 3 Mental Illness Research, Education and Clinical Center|Bronx VA Medical Center PTSD July 2008 Not Applicable
NCT03710187 University of Tennessee Medical Center Septic Shock November 5, 2018 Phase 2
NCT00415701 University Hospital Inselspital, Berne Coronary Artery Disease|Mitral Valve Regurgitation November 2006 Phase 4
NCT01859312 National Institutes of Health Clinical Center (CC)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Adrenal Insufficiency|Excess Androgen|Congenital Adrenal Hyperplasia (CAH) May 6, 2013 Phase 2
NCT00933023 Chelsea and Westminster NHS Foundation Trust Phimosis August 2009 Phase 4
NCT00621985 Boston Children´s Hospital Adrenal Hyperplasia, Congenital April 2008 Phase 2
NCT03465007 University of Jordan Dialysis Hypotension October 22, 2017 Not Applicable
NCT01847690 Haukeland University Hospital Addison Disease June 2013 Phase 2
NCT02425852 Groupe d´Etude Therapeutique des Affections Inflammatoires Digestives Ulcerative Colitis December 2016 Phase 4
NCT02408939 University of Athens|University of Thessaly Infections|Cardiac Arrest March 2015
NCT00657306 University of Turin, Italy Cirrhosis With Ascites May 2008 Phase 2
NCT00400946 Dana-Farber Cancer Institute|National Cancer Institute (NCI) Drug+Agent Toxicity by Tissue+Organ|Leukemia April 2005 Phase 3
NCT00002970 National Cancer Institute (NCI)|Children´s Cancer Group Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Lymphoblastic Lymphoma|T-cell Childhood Acute Lymphoblastic Leukemia June 1997 Phase 2
NCT03261336 Donald Trump, MD|Inova Health Care Services Castration-resistant Prostate Cancer January 6, 2017 Phase 2
NCT02229136 US Oncology Research|Novartis Pharmaceuticals Stomatitis|Oral Mucositis|Neoplasm of the Breast|Malignant Tumor of Breast September 4, 2014 Phase 2
NCT00004669 National Center for Research Resources (NCRR)|Penn State University|Office of Rare Diseases (ORD) Bronchopulmonary Dysplasia June 1996 Phase 2
NCT02112019 Derk Jan Jager|VU University Medical Center Sjögren´s Syndrome June 2014 Not Applicable
NCT01574014 University Hospital Inselspital, Berne|University of Basel Phobic Disorders|Phobias July 2009 Phase 2
NCT00334672 Children´s Cancer and Leukaemia Group|National Cancer Institute (NCI) Nonneoplastic Condition March 2006 Phase 3
NCT01450930 Bruno Allolio|University of Wuerzburg Primary Adrenal Insufficiency November 2011 Phase 2
NCT03358082 Sohag University Vitiligo|Tacrolimus October 1, 2017 Phase 1|Phase 2
NCT00172354 National Taiwan University Hospital Heart Arrest October 2004 Not Applicable
NCT02473263 Assistance Publique - Hôpitaux de Paris Severe Septic Syndrome (Severe Sepsis and Septic Shock) Diagnosed and Treated by Mobile Intensive Care Unit May 9, 2016 Phase 3
NCT01828515 University of Texas Southwestern Medical Center|Forest Laboratories Memory Impairment December 2012 Phase 2
NCT01761344 Haukeland University Hospital Primary Hyperaldosteronism January 2013 Not Applicable
NCT00706173 University of California, San Diego Post-traumatic Stress Disorder August 2009 Phase 4
NCT00676585 Beth Israel Deaconess Medical Center|American Heart Association Cardiac Arrest October 2007 Phase 1|Phase 2
NCT01525680 Bronx VA Medical Center|United States Department of Defense Post Traumatic Stress Disorder April 2011 Not Applicable
NCT00002798 National Cancer Institute (NCI) Childhood Acute Erythroleukemia (M6)|Childhood Acute Megakaryocytic Leukemia (M7)|Childhood Acute Monoblastic Leukemia (M5a)|Childhood Acute Monocytic Leukemia (M5b)|Childhood Acute Myeloblastic Leukemia With Maturation (M2)|Childhood Acute Myeloblastic Leukemia Without Maturation (M1)|Childhood Acute Myelomonocytic Leukemia (M4)|Childhood Myelodysplastic Syndromes|Chronic Myelomonocytic Leukemia|de Novo Myelodysplastic Syndromes|Refractory Anemia|Refractory Anemia With Excess Blasts|Refractory Anemia With Excess Blasts in Transformation|Refractory Anemia With Ringed Sideroblasts|Secondary Myelodysplastic Syndromes|Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies August 1996 Phase 3
NCT00623766 Bristol-Myers Squibb|Medarex Melanoma July 2008 Phase 2
NCT00688987 Oregon Health and Science University Obesity|Addison´s Disease August 2000 Not Applicable
NCT03335774 Nivagen Pharmaceuticals Inc. Internal Hemorrhoids October 1, 2018 Phase 2
NCT01156480 NorthShore University HealthSystem Research Institute|University of Chicago Necrotizing Enterocolitis September 2009 Not Applicable
NCT00049569 National Cancer Institute (NCI) L1 Childhood Acute Lymphoblastic Leukemia|L2 Childhood Acute Lymphoblastic Leukemia|Non-T, Non-B Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia|T-cell Childhood Acute Lymphoblastic Leukemia January 2003 Not Applicable
NCT02112916 National Cancer Institute (NCI) Adult T Acute Lymphoblastic Leukemia|Ann Arbor Stage II Adult Lymphoblastic Lymphoma|Ann Arbor Stage II Childhood Lymphoblastic Lymphoma|Ann Arbor Stage III Adult Lymphoblastic Lymphoma|Ann Arbor Stage III Childhood Lymphoblastic Lymphoma|Ann Arbor Stage IV Adult Lymphoblastic Lymphoma|Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma|Childhood T Acute Lymphoblastic Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia September 30, 2014 Phase 3
NCT01399268 Hospital for Special Surgery, New York Postoperative Inflammatory Response February 2009 Phase 4
NCT02735707 MJM Bonten|Berry Consultants|Australian and New Zealand Intensive Care Research Centre|Medical Research Institute of New Zealand|UMC Utrecht Community-Acquired Pneumonia April 11, 2016 Phase 4
NCT01559675 Cedars-Sinai Medical Center Orthostatic Hypotension|Hemodynamic Instability|Fever|Hypothermia September 2010 Not Applicable
NCT00507832 University Hospital Muenster|Novartis Pharmaceuticals Prurigo Nodularis April 2007 Phase 2
NCT01546922 University Medical Center Groningen Adrenal Insufficiency February 2012 Phase 4
NCT00673127 Beth Israel Deaconess Medical Center|Massachusetts General Hospital|Dana-Farber Cancer Institute|Sunnybrook Health Sciences Centre|Oregon Health and Science University|M.D. Anderson Cancer Center|Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Prostate Cancer February 2005 Phase 2
NCT00670254 Charite University, Berlin, Germany|German Federal Ministry of Education and Research|German Competence Network Sepsis|Coordination Centre for Clinical Trials Leipzig Severe Sepsis January 2009 Phase 3
NCT00003215 Swiss Group for Clinical Cancer Research Lymphoma April 1997 Phase 3
NCT00442390 University of Aarhus Addison Syndrome January 2002 Not Applicable
NCT02481310 Northwestern University|National Cancer Institute (NCI)|Millennium Pharmaceuticals, Inc. Adult Burkitt Lymphoma|B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma|Diffuse Large B-Cell Lymphoma|MYC Gene Mutation|Plasmablastic Lymphoma September 2015 Phase 1|Phase 2
NCT01007591 LEO Pharma Psoriasis Vulgaris October 2009 Phase 3
NCT00002700 European Organisation for Research and Treatment of Cancer - EORTC|Acute Leukemia French Association Leukemia|Lymphoma August 1995 Phase 3
NCT03760835 Federico II University Congenital Adrenal Hyperplasia August 11, 2016 Phase 4
NCT02084134 Washington University School of Medicine Pituitary Adenoma|Pituitary Diseases March 2012 Not Applicable
NCT02790788 University of Athens|University of Thessaly Inhospital Cardiac Arrest November 4, 2016 Phase 1|Phase 2
NCT01771328 Haukeland University Hospital Adrenal Hyperplasia, Congenital February 2013 Phase 2
NCT02575001 University of Ljubljana, Faculty of Medicine Type 1 Diabetes|Stress July 2015
NCT01422733 University of Virginia Hyperandrogenemia|Obesity|Polycystic Ovary Syndrome June 1, 2018 Early Phase 1
NCT00186628 Stanford University|The Leukemia and Lymphoma Society|National Cancer Institute (NCI) Leukemia, Mast-Cell|Mantle-cell Lymphoma June 2005 Phase 2
NCT02883049 National Cancer Institute (NCI) B Acute Lymphoblastic Leukemia|Central Nervous System Leukemia|Ph-Like Acute Lymphoblastic Leukemia|Testicular Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia February 27, 2012 Phase 3
NCT01782859 Hospital for Special Surgery, New York Total Hip Replacement October 2012 Not Applicable
NCT00019409 National Institutes of Health Clinical Center (CC)|National Cancer Institute (NCI) Leukemia October 1999 Phase 3
NCT02090309 Soroka University Medical Center Injuries, Whiplash March 2014 Phase 2
NCT01150409 The Cleveland Clinic Septic Shock May 2008 Phase 4
NCT00550992 Dutch Childhood Oncology Group|BFM Germany|CORS Monza Italy|Associazione Italiana Ematologia Oncologia Pediatrica|Australian and New Zealand Children´s Oncology Group|BFM Austria|CLCG France Belgium Portugal|COALL Germany|CPH, Czech republic|DFCI consortium USA|FRALLE France|Hong Kong|MD Anderson USA|NOPHO Scandinavian countries|PINDA, Chile|PPLLSG Poland|Seattle USA|SJCRH USA|UKCCSG United Kingdom Leukemia June 2007 Not Applicable
NCT00002816 Children´s Oncology Group|National Cancer Institute (NCI) Leukemia December 1996 Phase 3
NCT02552654 Charite University, Berlin, Germany Intrusive Memories September 2015 Not Applicable
NCT01108146 Central Institute of Mental Health, Mannheim|German Research Foundation Posttraumatic Stress Disorder October 2008 Not Applicable
NCT02114710 Nanjing PLA General Hospital Coagulation Dysfunction in Septic Shock|Hemodynamic Improvement Induced by Hydrocortisone May 2009 Phase 3
NCT00597857 Kent State University|National Institute of Mental Health (NIMH) Posttraumatic Stress Disorder June 2005 Not Applicable
NCT03539601 Pfizer Atopic Dermatitis April 27, 2018 Phase 4
NCT02535806 Children´s Mercy Hospital Kansas City|Millennium Pharmaceuticals, Inc. Acute Lymphoblastic Leukemia|Lymphoblastic Lymphoma July 2015 Phase 2
NCT01144065 Meir Medical Center Acute Myocardial Infarction August 2010
NCT00674570 VA Office of Research and Development Stress Disorders, Posttraumatic July 1, 2008 Phase 4
NCT03217760 University Hospital, Brest Endodontic Treatment March 28, 2017
NCT00915343 Shire Adrenal Insufficiency August 2007 Phase 2|Phase 3
NCT00002756 Children´s Oncology Group|National Cancer Institute (NCI) Leukemia June 1996 Phase 2
NCT03286634 National Hospital Organization Nagoya Medical Center Down Syndrome|Acute Lymphoblastic Leukemia|Childhood Cancer April 18, 2018 Phase 2
NCT02959580 Peking Union Medical College Hospital Granulomatous Mastitis January 1, 2017 Phase 4
NCT02270827 Royal Brompton & Harefield NHS Foundation Trust Asthma June 2014
NCT01769339 Janssen Pharmaceutica Vulva; Candidiasis January 2009 Phase 4
NCT00320099 University of Versailles|Assistance Publique - Hôpitaux de Paris Septic Shock January 2006 Phase 3
NCT02230930 University Medical Center Groningen Parkinson´s Disease|Apomorphine-induced Skin Reactions June 2015 Phase 2
NCT00186264 Stanford University|Wyeth is now a wholly owned subsidiary of Pfizer Depressive Disorder, Major August 2002 Not Applicable
NCT00097474 Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Institutes of Health Clinical Center (CC) Jet Lag Syndrome November 22, 2004 Phase 2
NCT02523664 Charite University, Berlin, Germany Borderline Personality Disorder|PTSD January 2014 Not Applicable
NCT00368381 CAMC Health System Sepsis|Adrenal Insufficiency September 2006 Phase 4
NCT01284452 Mahidol University Septic Shock|Severe Sepsis|Acute Lung Injury|Acute Respiratory Distress Syndrome December 2010 Not Applicable
NCT03020030 Dana-Farber Cancer Institute|Shire Acute Lymphoblastic Leukemia, Pediatric March 3, 2017 Phase 3
NCT01230983 Children´s Oncology Group|National Cancer Institute (NCI) Cardiac Toxicity|Leukemia|Lymphoma June 1996 Phase 3
NCT03758365 Drug Delivery Solutions Ltd. (part of MC2 Therapeutics) Vasoconstriction November 5, 2018 Phase 1
NCT02777268 Diurnal Limited|Simbec Research Healthy Subjects July 2013 Phase 1
NCT02270788 St. Jude Children´s Research Hospital|Arog Pharmaceuticals, Inc.|Ohio State University Acute Myeloid Leukemia April 2, 2015 Phase 1
NCT03592693 University of Athens|General Hospital of Nikaia ?Saint Panteleimon?|Naval Hospital, Athens Shock, Septic September 6, 2018 Phase 2
NCT00027859 Eastern Cooperative Oncology Group|National Cancer Institute (NCI)|Southwest Oncology Group|Cancer and Leukemia Group B Prostate Cancer May 2003 Phase 3
NCT00149123 Hospices Civils de Lyon Burns April 2005 Phase 4
NCT01156519 Nantes University Hospital Obesity June 2010 Not Applicable
NCT01451515 St. Jude Children´s Research Hospital|National University, Singapore Lymphoblastic Lymphoma May 25, 2012 Phase 2
NCT00557193 Children´s Oncology Group|National Cancer Institute (NCI) Acute Lymphoblastic Leukemia|Acute Undifferentiated Leukemia|Childhood T Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia January 14, 2008 Phase 3
NCT03422159 Community Medical Center, Toms River, NJ Sepsis, Severe|Septic Shock February 5, 2018 Phase 2
NCT01093261 Nantes University Hospital|Société Française d´Anesthésie et de Réanimation Traumatic Brain Injury|Trauma|Adrenal Insufficiency|Pneumonia August 2010 Phase 3
NCT01055249 X-pert Med GmbH Pain|Inflammation|Healthy Volunteers January 2010 Phase 1
NCT02196142 University Hospital Inselspital, Berne Alcohol Craving|Psychological Stress|Physiological Stress November 2014 Phase 3
NCT02360046 University Hospital Inselspital, Berne Hypopituitarism|Hydrocortisone|Lipids|Fatty Acids, Nonesterified|Insulin Sensitivity January 2015 Not Applicable
NCT02001207 Seoul National University Hospital Critically Ill July 2013
NCT00759005 National Institute on Drug Dependence, China Heroin Dependence|Learning and Memory March 2007 Not Applicable
NCT00396344 Dartmouth-Hitchcock Medical Center|National Institute of Allergy and Infectious Diseases (NIAID) Sepsis October 2006 Not Applicable
NCT02044159 Children´s Hospital of Eastern Ontario|Alberta Children´s Hospital|British Columbia Children´s Hospital|London Health Sciences Centre|St. Justine´s Hospital|IWK Health Centre|Montreal Children´s Hospital of the MUHC Shock July 2014 Phase 4
NCT02580240 Northern Jiangsu Province People´s Hospital Septic Shock September 2015 Not Applicable
NCT01460615 Tampere University Hospital Postoperative Complications|Postoperative Pancreatitis February 2011 Phase 2
NCT03282487 The Adelaide and Meath Hospital, incorporating The National Children´s Hospital Adrenal Insufficiency September 5, 2017 Phase 4
NCT00953576 Dana-Farber Cancer Institute|Beth Israel Deaconess Medical Center|Brigham and Women´s Hospital|Massachusetts General Hospital|Prostate Cancer Foundation Clinical Research Consortium|GlaxoSmithKline Prostate Cancer September 29, 2009 Phase 1|Phase 2
NCT00002471 Memorial Sloan Kettering Cancer Center Leukemia|Lymphoma February 1990 Phase 2
NCT02289989 Rutgers, The State University of New Jersey Atopic Dermatitis November 2014 Not Applicable
NCT03558971 Helen Foundation Rheumatic Diseases January 1, 2000 Phase 4
NCT01700946 St. Jude Children´s Research Hospital|Cookies for Kids´ Cancer|Assisi Foundation Recurrent B-Cell Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood B-Lymphoblastic Lymphoma April 15, 2013 Phase 2
NCT01036594 University of California, San Francisco Prostate Cancer December 11, 2009 Phase 2
NCT00729794 University of Athens|University of Thessaly Cardiac Arrest September 2008 Phase 3
NCT00131053 Japan Adult Leukemia Study Group Lymphoblastic Leukemia, Acute September 2002 Phase 2
NCT01614197 Therapeutic Advances in Childhood Leukemia Consortium|Pfizer Lymphoblastic Leukemia, Acute, Childhood|Lymphoblastic Lymphoma|Peripheral T-cell Lymphoma March 2015 Phase 1
NCT01595386 University of Alabama at Birmingham Heart Disease Congenital Complex April 2012 Not Applicable
NCT00853008 PETHEMA Foundation Acute Lymphoblastic Leukemia January 2003 Phase 4
NCT01422707 University of Virginia Hyperandrogenemia|Obesity|Polycystic Ovary Syndrome January 19, 2018 Early Phase 1
NCT03179813 University of Sao Paulo Impacted Third Molar Tooth May 1, 2017 Phase 4
NCT03389555 Beth Israel Deaconess Medical Center|Open Philanthropy Project Sepsis|Septic Shock|Metabolic Disturbance February 9, 2018 Phase 2|Phase 3
NCT00006371 H. Lee Moffitt Cancer Center and Research Institute|National Cancer Institute (NCI)|Janssen Pharmaceuticals Prostate Cancer May 2000 Phase 2
NCT03449797 University Hospital Padova Primary Aldosteronism Due to Aldosterone Producing Adenoma April 1, 2018 Not Applicable
NCT02190994 West China Hospital Pituitary Neoplasms|Craniopharyngiomas August 2013 Phase 4
NCT00003436 Medical Research Council|National Cancer Institute (NCI) Leukemia|Myelodysplastic Syndromes July 1998 Phase 3
NCT03792256 Children´s Oncology Group Leukemia, Lymphocytic|Lymphoblastic Lymphoma|T-cell Lymphoma|T-cell Leukemia|Recurrent Disease|Acute Leukemia January 3, 2019 Phase 1
NCT00526305 PETHEMA Foundation Acute Lymphoblastic Leukemia January 2000 Phase 4
NCT00185783 Stanford University|University of Toronto|University of Colorado, Denver Sepsis|Relative Adrenal Insufficiency March 2005
NCT03649633 University of Athens Septic Shock September 6, 2018 Phase 1|Phase 2
NCT02760862 Ain Shams University Headache October 2014 Phase 4
NCT00618501 Asan Medical Center|National Cancer Institute (NCI) Leukemia October 2005 Phase 2
NCT00002760 Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) Prostate Cancer August 1996 Phase 3
NCT00002805 Children´s Oncology Group|National Cancer Institute (NCI) Leukemia August 1997 Phase 2
NCT02152553 Vastra Gotaland Region Addison Disease May 2014 Not Applicable
NCT01353313 NICHD Neonatal Research Network|National Center for Research Resources (NCRR)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|National Heart, Lung, and Blood Institute (NHLBI) Infant, Newborn|Infant, Small for Gestational Age|Infant, Very Low Birth Weight|Infant, Premature|Bronchopulmonary Dysplasia September 2011 Phase 3
NCT00675272 Kuopio University Hospital|Tampere University Hospital Brain Death May 2008 Not Applicable
NCT00563303 Nantes University Hospital|Serb Polytraumatism November 2006 Phase 2|Phase 3
NCT00873093 National Cancer Institute (NCI) B-cell Adult Acute Lymphoblastic Leukemia|B-cell Childhood Acute Lymphoblastic Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult Lymphoblastic Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Lymphoblastic Lymphoma|T-cell Adult Acute Lymphoblastic Leukemia|T-cell Childhood Acute Lymphoblastic Leukemia March 2009 Phase 2
NCT00002855 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Prostate Cancer August 1996 Phase 3
NCT00529841 Baylor College of Medicine Adrenal Hyperplasia, Congenital January 2007 Not Applicable
NCT02691858 Cairo University Intussusception April 2015 Not Applicable
NCT00002552 Barbara Ann Karmanos Cancer Institute|National Cancer Institute (NCI) Lymphoma|Multiple Myeloma and Plasma Cell Neoplasm October 1993 Phase 2
NCT01815918 Hospital for Special Surgery, New York Total Knee Arthroplasty February 2011 Phase 4
NCT02266589 Nanjing PLA General Hospital Septic Shock|Sepsis November 2011 Phase 3
NCT00691002 LEO Pharma Psoriasis Vulgaris May 2008 Phase 3
NCT02266264 Srinakharinwirot University Hyperglycemia October 2014 Phase 4
NCT00133991 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|National Cancer Institute (NCI) Leukemia|Lymphoma July 2005 Phase 2
NCT00801957 Astellas Pharma Inc Atopic Dermatitis March 2003 Phase 2
NCT00451750 University of Zurich|University Hospital, Basel, Switzerland Phobia May 2007 Not Applicable
NCT02478021 Charite University, Berlin, Germany Individuality September 2014 Not Applicable
NCT03237689 Johns Hopkins University|National Institute of Mental Health (NIMH) Hiv November 20, 2017 Early Phase 1
NCT02837432 Stanford University Depression July 2016 Early Phase 1
NCT03142893 Los Angeles Biomedical Research Institute Sleep Restriction May 8, 2017 Phase 1
NCT02402114 Albert Einstein Healthcare Network Post-Traumatic Stress Disorder February 2, 2015 Not Applicable
NCT01064986 Rutgers, The State University of New Jersey Infections February 2010 Phase 1
NCT02505815 University of Erlangen-Nürnberg Medical School Neurocognitive Function September 2014
NCT02116608 University of Colorado, Denver Granuloma|Tracheostomy September 2014 Phase 4
NCT00536991 Roswell Park Cancer Institute|National Cancer Institute (NCI) Prostate Adenocarcinoma|Recurrent Prostate Carcinoma|Stage III Prostate Cancer|Stage IV Prostate Cancer October 2006 Phase 1|Phase 2
NCT00096135 Children´s Oncology Group|National Cancer Institute (NCI) Leukemia November 2004 Not Applicable
NCT02408068 Diurnal Limited|Simbec Research Healthy January 2015 Phase 1
NCT00098839 Children´s Oncology Group|National Cancer Institute (NCI) Recurrent Childhood Acute Lymphoblastic Leukemia February 2005 Phase 1|Phase 2
NCT00773058 Southeast University, China|Nanjing Medical University Acute Respiratory Distress Syndrome|Adrenal Insufficiency December 2008 Phase 4
NCT00354107 National Cancer Institute (NCI) Anaplastic Large Cell Lymphoma|Recurrent Childhood Anaplastic Large Cell Lymphoma January 2007 Phase 1|Phase 2
NCT00559481 Roswell Park Cancer Institute|National Cancer Institute (NCI) Prostate Cancer October 2007 Not Applicable
NCT02828358 National Cancer Institute (NCI) Acute Leukemia of Ambiguous Lineage|Childhood B Acute Lymphoblastic Leukemia|KMT2A Gene Rearrangement|Mixed Phenotype Acute Leukemia March 27, 2017 Phase 2
NCT00442494 Kuopio University Hospital|Tampere University Hospital|Oulu University Hospital Atrial Fibrillation October 2012 Not Applicable
NCT00057811 Children´s Oncology Group|National Cancer Institute (NCI) Childhood Burkitt Lymphoma|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Stage I Childhood Large Cell Lymphoma|Stage I Childhood Small Noncleaved Cell Lymphoma|Stage II Childhood Large Cell Lymphoma|Stage II Childhood Small Noncleaved Cell Lymphoma|Stage III Childhood Large Cell Lymphoma|Stage III Childhood Small Noncleaved Cell Lymphoma|Stage IV Childhood Large Cell Lymphoma|Stage IV Childhood Small Noncleaved Cell Lymphoma|Untreated Childhood Acute Lymphoblastic Leukemia June 2004 Phase 2
NCT00473083 British Columbia Cancer Agency|Hoffmann-La Roche Rash January 2009 Phase 2
NCT03766997 Peking Union Medical College Hospital Granulomatous Mastitis January 2019 Phase 4
NCT02714543 The Oxford Dental College, Hospital and Research Center, Bangalore, India Oral SubMucous Fibrosis November 2013 Phase 3
NCT00855270 Sheba Medical Center|National Institute of Mental Health (NIMH)|Icahn School of Medicine at Mount Sinai Post Traumatic Stress Disorder April 2009 Not Applicable
NCT03371784 Iuliu Hatieganu University of Medicine and Pharmacy|Romanian Governmental Funding (UEFISCDI) ST-segment Elevation Myocardial Infarction|Left Ventricular Remodeling March 8, 2018 Phase 2|Phase 3
NCT00002881 Eastern Cooperative Oncology Group|National Cancer Institute (NCI)|Cancer and Leukemia Group B|Southwest Oncology Group Prostate Cancer October 1996 Phase 3
NCT03062280 Diurnal Limited Congenital Adrenal Hyperplasia August 18, 2016 Phase 3
NCT03007147 Children´s Oncology Group|National Cancer Institute (NCI) B Acute Lymphoblastic Leukemia|BCR-ABL1 Fusion Protein Expression|Minimal Residual Disease|Philadelphia Chromosome Positive|T Acute Lymphoblastic Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia July 28, 2017 Phase 3
NCT03335124 University Medical Centre Ljubljana Sepsis|Septic Shock|Critical Illness|Fluid Overload September 26, 2017 Phase 4
NCT00625209 University of Versailles|Assistance Publique - Hôpitaux de Paris|Ministry of Health, France Septic Shock March 2008 Phase 3
NCT00181597 Genzyme, a Sanofi Company|Sanofi Prostate Cancer|Prostate Adenocarcinoma March 2004 Phase 2
NCT03012425 Memorial Sloan Kettering Cancer Center|Hunter College of City University of New York Insomnia|Related Distress Among Cancer Caregivers January 3, 2017 Not Applicable
NCT00693693 Wake Forest University|Wake Forest University Health Sciences Atopic Dermatitis November 2006 Phase 4
NCT01735617 Diurnal Limited|National Institutes of Health (NIH) Endocrine Disease|Adrenal Insufficiency|Congenital Adrenal Hyperplasia December 2012 Phase 2
NCT00236925 Ludwig-Maximilians - University of Munich|University of Zurich Fibromyalgia May 2003 Early Phase 1
NCT00185692 Stanford University Blood Cancer|Leukemia|Graft Versus Host Disease|Malignancy|CLL|NHL|Hodgkin´s Disease|MDS August 2000 Phase 2
NCT02256865 Los Angeles Biomedical Research Institute Insulin Resistance October 2014 Early Phase 1
NCT01014364 University of Versailles|Assistance Publique - Hôpitaux de Paris Pneumonia, Viral|Influenza in Humans March 2010 Phase 3
NCT01089075 Max-Planck-Institute of Psychiatry|Novo Nordisk A+S Partial Corticotrope Insufficiency February 2010 Phase 4
NCT01710202 University of Texas at Austin Major Depressive Disorder|Anxiety Disorders October 2012
NCT03682393 Kuopio University Hospital Atrial Fibrillation October 1, 2018 Phase 2|Phase 3
NCT03195933 University of Wisconsin, Madison|National Institute of Mental Health (NIMH)|Brain & Behavior Research Foundation Depression July 31, 2013 Not Applicable
NCT00482053 Stanford University Lymphoma, B-cell|Lymphoma, Non-Hodgkin|Diffuse Large B-cell Lymphoma (DLBCL)|Malignant Lymphoma, Non-Hodgkin October 2006 Phase 2
NCT03748537 Chiang Mai University Sepsis|Septic Shock January 1, 2017 Not Applicable
NCT03649009 Universiti Kebangsaan Malaysia Medical Centre Hyperlactatemia January 1, 2018 Not Applicable
NCT01718964 Prof. Dominique de Quervain, MD|University of Basel Opioid Dependence November 2012 Phase 2
NCT03548246 University of Texas Southwestern Medical Center|National Institutes of Health Clinical Center (CC)|University of Michigan|Children´s Hospital Los Angeles|Feinstein Institute for Medical Research Congenital Adrenal Hyperplasia September 2019 Phase 2
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (85.53 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.7589 mL 13.7946 mL 27.5893 mL
5 mM 0.5518 mL 2.7589 mL 5.5179 mL
10 mM 0.2759 mL 1.3795 mL 2.7589 mL
*Please refer to the solubility information to select the appropriate solvent.


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