A2942，两性霉素 B 溶液，SIGMA：

性质:

Related Categories	Antibiotic Solutions, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antifungal
InChI Key	APKFDSVGJQXUKY-INPOYWNPSA-N
sterility	0.1 μm filtered
product line	BioReagent
form	liquid
concentration	250 μg/mL in deionized water
application(s)	cell culture | mammalian: suitable
color	yellow
suitability	suitable for cell culture
Mode of action	cell membrane | interferes
antibiotic activity spectrum	fungi
	yeast
shipped in	dry ice
storage temp.	−20°C

产品描述:

Components

This product is supplied as 250 μg/mL Amphotericin B in deionized water. It is a solution containing Amphotericin B, and the following components aimed to improve its solubility: sodium deoxycholate, sodium chloride and sodium phosphate.

Application

Amphotericin B is a polyene antifungal antibiotic from Streptomyce sp. It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium.

Caution

Amphotericin B remains active for 3 days in culture at 37°C.

包装

20,50,100ml

Preparation Note

It is not unusual for this material to form a precipitate in aqueous solutions. Mixing the solution will redissolve most of the precipitate but, if it does not fully resolubilize, the Amphotericin B will still be suitable for use.

Biochem/physiol Actions

Amphotericin B solution has been used-
• as an intraperitoneal injection for the treatment of Aspergillus fumigatus infection in mice 
• as a constituent of aspiration medium for the culture of Chinese Merino ewe ovaries
• as a constituent of transport medium during the collection of equine corpora lutea 
• as a supplement in RPMI medium for the culture of the mouse-mouse B cell hybridoma 55-6 cell line

General description

Amphotericin B is a polyene antifungal antibiotic that is clinically used to treat systemic fungal infections. 

Chemical structure: polyene

Keep container tightly closed in a dry and well-ventilated place. Light sensitive.