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名称描述内容
5-Aza-2′-deoxycytidine
0.00
0.00
商品描述
A3656，5-Aza-2′-deoxycytidine ，SIGMA：
性质:
Related Categories
AN-AZ, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Eisai, Fluorination Ready Pharma-Developed Compounds,
Gene Regulation, Gene Regulation and Expression, 抗肿瘤药物, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学
InChI Key
XAUDJQYHKZQPEU-KVQBGUIXSA-N
assay
≥97%
solubility
acetic acid: water (1:1): 50 mg/mL
originator
Eisai
产品描述:
包装
5, 10 mg in glass bottle
50 mg in glass insert
Application
5-Aza-2′-deoxycytidine has been used as a demethylating agent in breast cancer cell line, chromatin, DNA and promoter region of p16 gene.
Biochem/physiol Actions
5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Eisai. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
5-Aza-2′-deoxycytidine is a DNA-hypomethylating agent, which stimulates differentiation and apoptosis of leukemic cells.It is a 2′-deoxycytidine analogue. 5-Aza-2′-deoxycytidine is used to treat chronic myelomonocytic leukemia, refractory anemia, myelodysplastic syndrome and acute myeloid leukemia.
性质:
| Related Categories |
AN-AZ, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Eisai, Fluorination Ready Pharma-Developed Compounds,
Gene Regulation, Gene Regulation and Expression, 抗肿瘤药物, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学
|
| InChI Key | XAUDJQYHKZQPEU-KVQBGUIXSA-N |
| assay | ≥97% |
| solubility | acetic acid: water (1:1): 50 mg/mL |
| originator | Eisai |
产品描述:
包装
5, 10 mg in glass bottle
50 mg in glass insert
Application
5-Aza-2′-deoxycytidine has been used as a demethylating agent in breast cancer cell line, chromatin, DNA and promoter region of p16 gene.
Biochem/physiol Actions
5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Eisai. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
5-Aza-2′-deoxycytidine is a DNA-hypomethylating agent, which stimulates differentiation and apoptosis of leukemic cells.It is a 2′-deoxycytidine analogue. 5-Aza-2′-deoxycytidine is used to treat chronic myelomonocytic leukemia, refractory anemia, myelodysplastic syndrome and acute myeloid leukemia.
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|
|
SIGMA
|
PVP360-100G
|
聚乙烯吡咯烷酮
|
100g
|
|
SIGMA
|
PVP360-500G
|
聚乙烯吡咯烷酮
|
500g
|
|
SIGMA
|
RTC000068-1L
|
Sodium
Azide 0.05% Solution
|
1L
|
|
SIGMA
|
S-6422
|
Na4P2O7×10H20
(NaPPi)
|
500G
|
|
SIGMA
|
S0130-1G
|
链脲佐菌素
|
1g
|
|
SIGMA
|
S0192-500ML
|
Hematopoietic
Stem Cell Expansion Medium
|
500ml
|
|
SIGMA
|
S0192-6X500ML
|
Stemline
II Hematopoietic Stem Cell Expansion Medium
|
1PK
|
|
SIGMA
|
S2626-1G
|
亚精胺
|
1g
|
|
SIGMA
|
S4641-1KG
|
柠檬酸钠
二水合物
|
1kg/瓶
|
|
SIGMA
|
S607-5G
|
水杨羟肟酸
|
5G
|
|
SIGMA
|
S6506-5G
|
Silver
nitrate
|
5g
|
|
SIGMA
|
S7907-500G
|
磷酸钠
二元
|
500g
|
|
SIGMA
|
S8032-25G
|
Sodium
azide
|
25g
|
|
SIGMA
|
S8636-100ML
|
Sodium
pyruvate solution
|
100ml
|
|
SIGMA
|
S9133-1MG
|
亚硒酸钠
|
1mg
|
|
SIGMA
|
S9637-100G
|
丁二酸钠
二元 六水合物
|
100G
|
|
SIGMA
|
SAB4200071-200UL
|
ANTI-FLAG
antibody, Rat monocl
|
200ul/支
|
|
SIGMA
|
SAB4200085-200UL
|
Monoclonal
Anti-AGO2 antibody
|
200ul/支
|
|
SIGMA
|
SAB4200539-200UL
|
Anti-Myocardin
antibody produc
|
200ul/支
|
|
SIGMA
|
SML0286-25MG
|
BMS753
|
|
|
SIGMA
|
SML0429-5MG
|
Ac-YVAD-cmk
|
5mg
|
|
SIGMA
|
SML0737-25MG
|
MitoTEMPO
|
25mg
|
|
SIGMA
|
SML0737-5MG
|
MitoTEMPO
|
5mg
|
|
SIGMA
|
SRP0221-20UG
|
PTPIA2
Active human
|
20ug
|
|
SIGMA
|
T0665-1G
|
holo-Transferrin
human
|
|
|
SIGMA
|
T0665-50MG
|
holo-Transferrin
|
50mg
|
|
SIGMA
|
T1077-10UG
|
Tissue
Inhibitor of Metalloproteinase-2 人
|
10ug
|
|
SIGMA
|
T4049-100ML
|
胰蛋白酶-EDTA
溶液
|
100ml
|
|
SIGMA
|
T4049-500ML
|
胰蛋白酶-EDTA
溶液
|
500ml
|
|
SIGMA
|
T4393-100UN
|
凝血酶
来源于人类血浆
|
100un
|
|
SIGMA
|
T4424-100ML
|
Trypsin
solution from porcine pancreas
|
100ml
|
|
SIGMA
|
T4424-500ML
|
Trypsin
solution from porcine pancreas
|
500ml
|
|
SIGMA
|
T48402-5G
|
2,2,2-三溴乙醇
|
5g/瓶
|
|
SIGMA
|
T4952-5MG
|
Tanshinone
IIA
|
5mg
|
|
SIGMA
|
T5168-100UL
|
Monoclonal
Anti-α-Tubulin antibody produced in mouse
|
100ul
|
|
SIGMA
|
T5941-100G
|
Trizma
盐酸盐
|
100g
|
|
SIGMA
|
T5941-500G
|
Trizma
盐酸盐
|
500g
|
|
SIGMA
|
T6522-25MG
|
胰蛋白酶抑制剂
|
25mg
|
|
SIGMA
|
T7009-100UN
|
凝血酶
来源于人类血浆
|
100un
|
|
SIGMA
|
T7009-1KU
|
凝血酶
|
1ku
|
|
SIGMA
|
T8203-100UL
|
Anti-α-Tubulin
antibody
|
100ul/支
|
|
SIGMA
|
T8787-50ML
|
Triton
X-100
|
50ml
|
|
SIGMA
|
T9284-100ML
|
Triton
X-100
|
100ml
|
|
SIGMA
|
T9531-5G
|
D-(+)-海藻糖
二水合物
|
5g/瓶
|
|
SIGMA
|
U120-1MG
|
U0126
monoethanolate
|
1mg/瓶
|
|
SIGMA
|
V900019-500G
|
柠檬酸
|
500g
|
|
SIGMA
|
V900058-500G
|
Sodium
chloride
|
500g
|
|
SIGMA
|
V900061-500G
|
Sodium
phosphate dibasic
|
500g
|
|
SIGMA
|
V900068-500G
|
Potassium
chloride
|
500g
|
|
SIGMA
|
V900095-500G
|
柠檬酸钠
|
500g
|
|
SIGMA
|
V900116-500G
|
蔗糖
|
500g
|
|
SIGMA
|
V900144-500G
|
甘氨酸
|
500g
|
|
SIGMA
|
V900408-100G
|
L-谷氨酸
|
100G
|
|
SIGMA
|
V900477-100G
|
HEPES
|
100g
|
|
SIGMA
|
V900483-500G
|
Trizma碱
|
500g
|
|
SIGMA
|
V900510-100G
|
琼脂糖
|
100g/瓶
|
|
SIGMA
|
V900548-500ML
|
TWEEN
20
|
500ml
|
|
SIGMA
|
V900853-25ML
|
TEMED
|
25ml
|
|
SIGMA
|
V900859-500G
|
十二烷基硫酸钠
|
500g
|
|
SIGMA
|
V900883-25G
|
过硫酸铵(AP)
|
25g
|
|
SIGMA
|
V900930-1MG
|
雷帕霉素
|
1mg
|
|
SIGMA
|
Y1625-250G
|
Yeast
Extract
|
250g
|
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