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首页 ∷ 试剂 ∷ 近岸蛋白 ∷ Recombinant Human B7-H3 (C-6His)(Cat. No.:CK62)
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Recombinant Human B7-H3 (C-6His)(Cat. No.:CK62)

Recombinant Human B7-H3 (C-6His)(Cat. No.:CK62)

Recombinant Human B7 Homolog 3 is produced by our Mammalian expression system and the target gene encoding Leu29-Thr461 is expressed with a 6His tag at the C-terminus.

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商品描述

Recombinant Human B7 Homolog 3 is produced by our Mammalian expression system and the target gene encoding Leu29-Thr461 is expressed with a 6His tag at the C-terminus.

产品描述
Recombinant Human B7 Homolog 3 is produced by our Mammalian expression system and the target gene encoding Leu29-Thr461 is expressed with a 6His tag at the C-terminus.
蛋白编号
Q5ZPR3
产品别称
CD276; B7H34Ig-B7-H3; B7-H3; B7 homolog 3; CD276 antigen; CD276 molecule; Costimulatory molecule
分子量
47.3 KDa
表观分子量
65-90 KDa, reducing conditions
剂型描述
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
内毒素
Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
纯度
Greater than 95% as determined by reducing SDS-PAGE.
生物活性
Loaded Anti-Human B7-H3 mAb-Fc(Cat#NC055) on Protein A Biosensor, can bind Human B7-H3-His(Cat#CK62) with an affinity constant of 0.7 nM as determined in BLI assay. 
复溶

  • Always centrifuge tubes before opening.Do not mix by vortex or pipetting.

  • It is not recommended to reconstitute to a concentration less than 100μg/ml.

  • Dissolve the lyophilized protein in distilled water.

  • Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 

保存条件

  • Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.

  • Reconstituted protein solution can be stored at 4-7°C for 2-7 days.

  • Aliquots of reconstituted samples are stable at < -20°C for 3 months.

运输条件

  • The product is shipped at ambient temperature.

  • Upon receipt, store it immediately at the temperature listed below.

产品背景
CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20–27% amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration.
仅供科研或生产使用，不可直接应用于人体。