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Recombinant Human RANK L(Cat. No.:CK63)

Recombinant Human RANK L(Cat. No.:CK63)

Recombinant Human Receptor Activator of NF-kappa-B Ligand is produced by our E.coli expression system and the target gene encoding Ile140-Asp317 is expressed.

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商品描述

Recombinant Human Receptor Activator of NF-kappa-B Ligand is produced by our E.coli expression system and the target gene encoding Ile140-Asp317 is expressed.

产品描述
Recombinant Human Receptor Activator of NF-kappa-B Ligand is produced by our E.coli expression system and the target gene encoding Ile140-Asp317 is expressed.
蛋白编号
O14788
产品别称
CD254; ODF; OPGL; RANK L; TNFSF11; CD254; Osteoclast differentiation factor; Receptor activator of nuclear factor kappa-B ligand; tumor necrosis factor ligand superfamily member 11
分子量
22.4 KDa
表观分子量
20 KDa, reducing conditions
剂型描述
Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
内毒素
Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
纯度
Greater than 90% as determined by reducing SDS-PAGE.
复溶

  • Always centrifuge tubes before opening.Do not mix by vortex or pipetting.

  • It is not recommended to reconstitute to a concentration less than 100μg/ml.

  • Dissolve the lyophilized protein in distilled water.

  • Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 

保存条件

  • Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.

  • Reconstituted protein solution can be stored at 4-7°C for 2-7 days.

  • Aliquots of reconstituted samples are stable at < -20°C for 3 months.

运输条件

  • The product is shipped at ambient temperature.

  • Upon receipt, store it immediately at the temperature listed below.

产品背景
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.
仅供科研或生产使用，不可直接应用于人体。