Guanidine thiocyanate (GTC) is a powerful protein denaturant and can denature endogenous ribonucleases.It plays a role in separation of ribosomal ribonucleic acid (rRNA) from ribosomes.GTC in combination with phenol and chloroform can be used in isolation of total RNA from cells and tissues
一般描述
离液剂（Chaotropic agent）和强变性剂，用于变性裂解细胞；提取RNA和DNA。
Guanidine thiocyanate has been used:
· for the lysis of colorectal adenocarcinoma cell line prior to RNA isolation
· as a PCR inhibitor in triplex mitochondrial DNA (mtDNA) qPCR assay
· for DNA extraction from cerebrospinal fluid (CSF)
