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首页 ∷ 试剂 ∷ 阿拉丁 ∷ M129460 米托蒽醌二盐酸盐 ,≥97%
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M129460 米托蒽醌二盐酸盐 ,≥97%

M129460 米托蒽醌二盐酸盐 ,≥97%

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商品描述

基本信息

产品名称米托蒽醌二盐酸盐
英文名称Mitoxantrone dihydrochloride
别名盐酸米托蒽醌；1,4-二羟基-5,8-双-[[2-[（2-羟乙基）氨基] 乙基] 氨基]-9,10-蒽二酮 二盐酸盐；米托蒽醌二盐酸盐；1,4-二羟基-5,8-双[[2-[(2-羟乙基)氨基]乙基]氨基]蒽醌二盐酸盐；1,4-二羟基-5,8-双[[2-[(2-羟乙基)氨基]乙基]氨基]蒽-9,10-二酮二盐酸盐
英文别名Novantrone dihydrochloride; 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride;1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone Dihydrochloride;1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyeth
应用Induces DNA damage by intercalating into DNA and inhibiting Topo II;It can be used to induce calreticulin surface expression in cells， as a genotoxin agent，as a topoisomerase inhibitor.
规格或纯度≥97%
运输条件超低温冰袋运输
生化机理Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. It used clinically as a chemotherapeutic agent against leukemias and solid tumors and as an immune system modulator in multiple sclerosis. .Type II topoisomerase inhibitor (IC 50 = 50 nM). Able to inhibit DNA and protein synthesis, and induce both DNA strand breakage and cross linkage. Antineoplastic, immunomodulatory and chemotherapeutic action.

一般描述

Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.Induces DNA damage by intercalating into DNA and inhibiting Topo II;It can be used to induce calreticulin surface expression in cells， as a genotoxin agent，as a topoisomerase inhibitor.


Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation.
Induces DNA damage by intercalating into DNA and inhibiting Topo II;It can be used to induce calreticulin surface expression in cells， as a genotoxin agent，as a topoisomerase inhibitor.


相关属性

CAS编号70476-82-3
敏感性对热敏感
熔点267 °C(dec.)
溶解性Soluble in water (89 mg/ml at 25 °C), 100% ethanol (slightly), methanol (slightly), and DMSO (89 mg/ml at 25 °C). Insoluble in acetone.
储存温度-20°C储存
MDL号MFCD00242943
分子量517.4
分子式C22H28N4O6·2HCl
品牌阿拉丁
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关联CAS65271-80-9
PubChem CID51082