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首页 ∷ 试剂 ∷ 阿拉丁 ∷ T127039 Tideglusib,非ATP竞争性GSK-3β抑制剂 ,≥98%
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T127039 Tideglusib,非ATP竞争性GSK-3β抑制剂 ,≥98%

T127039 Tideglusib,非ATP竞争性GSK-3β抑制剂 ,≥98%

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商品描述

基本信息

产品名称Tideglusib,非ATP竞争性GSK-3β抑制剂
英文名称Tideglusib
别名NP-12;NP031112
英文别名NP 031112;NP-031112;4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione
规格或纯度≥98%
运输条件超低温冰袋运输
生化机理Tideglusib, also known as NP031112 or NP-12, is a potent non ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK3), an important kinase studied in stem cell research and neurodegenerative diseases. It is currently in clinical trials for Alzheimer′s disease and Progressive Supranuclear Palsy (PSP). Tideglusib reduces phosphorylation of the tau protein and the accumulation of amyloid plaques, reduces hippocampal and entorhinal cortex neuron loss and improves spatial memory deficits. It has also shown neuroprotective and anti-inflammatory activity in a variety of animal models.

一般描述

Tideglusib(NP-031112)是不可逆的非ATP竞争性GSK-3β抑制剂，IC50为60 nM。


Tideglusib is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site.


相关属性

CAS编号865854-05-3
溶解性DMSO 1 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
储存温度-20°C储存
MDL号MFCD18633296
分子量334.39
分子式C19H14N2O2S
品牌阿拉丁
备注5mg、100mg卖完停产，不再备货
PubChem CID11313622